Anti-Mouse PD-L2 (B7-DC) In Vivo Antibody - Ultra Low Endotoxin

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SKU:
IVMB0351
Product Type:
In Vivo Monoclonal Antibody
Clone:
TY25
Protein:
PD-L2
Isotype:
IgG2a k
Reactivity:
Mouse
Synonyms:
PD-L2
Synonyms:
CD273
Synonyms:
B7-DC
Research Area:
Costimulatory Molecules
Research Area:
Immunology
Endotoxin Level:
Ultra Low Endotoxin
Host Species:
Rat
Applications:
FC
Applications:
IHC FF
Applications:
In Vivo
Applications:
IP
Applications:
WB

Description

Product Name:Anti-Mouse PD-L2 (B7-DC) In Vivo Antibody - Ultra Low Endotoxin
Product Code:IVMB0351
Size:1 mg, 5 mg, 25 mg, 50 mg, 100 mg
Clone:TY25
Protein:PD-L2
Product Type:Monoclonal Antibody
Synonyms:PD-L2 , CD273, B7-DC
Isotype:IgG2a k
Reactivity:Mouse
Applications:FC, IHC FF, In Vivo, IP, WB
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Endotoxin Level:≤ 0.5 EU/mg as determined by the LAL method
Purity:≥98% monomer by analytical SEC ⋅ >95% by SDS Page
Product Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Applications:FC, IHC FF, In Vivo, IP, WB
Reactivity:Mouse
Host Species:Rat
Specificity:Clone TY25 recognizes an epitope on mouse PD-L2. TY25 does not cross-react with PD-L1.
Antigen Distribution:PD-L2 is expressed on macrophages and a subset of dendritic cells (DCs).
Immunogen:Purified transfected mouse B7-DC cell line
Concentration:≥ 5.0 mg/ml
Endotoxin Level:≤ 0.5 EU/mg as determined by the LAL method
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Purity:≥98% monomer by analytical SEC ⋅ >95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

PD-L2 antibody, clone TY25, recognizes mouse programmed death ligand 2 (PDL-2), also known as B7-DC and CD273. PD-L2 is a 42 kDa type I transmembrane glycoprotein that belongs to the B7 family of the immunoglobulin (Ig) receptor superfamily. PD-L2 is an inhibitory ligand primarily expressed on antigen-presenting cells, including macrophages and a subset of dendritic cells (DCs). Its receptor, PD-1, is expressed by CD4-CD8- thymocytes as well as CD4 and CD8 T cells, monocytes, DCs, and B cells upon activation1. Binding of PD-L2 to PD-1 on CD4 and CD8 T cells inhibits T cell receptor (TCR) signaling, negatively regulating T cell proliferation, cytokine production, and cytotoxic activity2. PD-L2 is expressed on many tumor types3,4 and is associated with unfavorable prognosis in patients with solid tumors5.

Protein:PD-L2
Ligand/Receptor:PD-1, uncharacterized receptor
Research Area:Costimulatory Molecules, Immunology
Pathogen Testing:To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Assay Genie's Purified Functional Antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile.
Shipping:2-8°C
PubMed:PD-L2
NCBI Gene Bank ID:58205
UniProt:CD273
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