Anti-Mouse IL-4 In Vivo Antibody - Low Endotoxin

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SKU:
IVMB0365
Product Type:
In Vivo Monoclonal Antibody
Clone:
BVD6-24G2
Protein:
IL-4
Isotype:
IgG1 k
Reactivity:
Mouse
Synonyms:
BCGF
Synonyms:
BCDF
Synonyms:
B Cell Stimulating Factor
Synonyms:
BSF-1
Synonyms:
IaIF
Synonyms:
HCGF
Synonyms:
MCGF2
Synonyms:
MFF
Synonyms:
TCGF-2
Research Area:
Cell Biology
Research Area:
Stem Cell
Endotoxin Level:
Low Endotoxin
Host Species:
Rat
Applications:
In Vivo
Applications:
WB

Description

Product Name:Anti-Mouse IL-4 In Vivo Antibody - Low Endotoxin
Product Code:IVMB0365
Size:0.5 mg, 1 mg
Clone:BVD6-24G2
Protein:IL-4
Product Type:Monoclonal Antibody
Synonyms:BCGF, BCDF, B Cell Stimulating Factor, BSF-1, IaIF, HCGF, MCGF2, MFF, TCGF-2
Isotype:IgG1 k
Reactivity:Mouse
Applications:In Vivo, WB
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC ⋅ >95% by SDS Page
Product Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Applications:In Vivo, WB
Reactivity:Mouse
Host Species:Rat
Specificity:Clone BVD6-24G2 recognizes an epitope on mouse IL-4.
Immunogen:Purified Recombinant Mouse IL-4 (>98%)
Concentration:≥ 5.0 mg/ml
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Purity:≥95% monomer by analytical SEC ⋅ >95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

IL-4 is a 15-19 kD pleiotropic immune cytokine secreted by activated TH2 cells. It has many biological roles, including the regulation in humoral and adaptive immunity, the inhibition of bone resorption, the stimulation of activated B-cell and T-cell proliferation, and initiation of allergic responses. Moreover, IL-4 induces a positive feedback loop by stimulating differentiation of naive helper T cells, or Th0 cells, to Th2 cells which in turn secrete more IL-4. Increased IL-4 production and overproduction of IL-4R are found in many cancers. IL-4 has a significant effect on tumor progression by increasing apoptosis resistance via tumor growth enhancement. IL-4 may also play a part in the immune dysregulation that occurs in most HIV-1 infected patients.

Protein:IL-4
Research Area:Cell Biology, Stem Cell
Shipping:2-8°C
PubMed:IL-4
NCBI Gene Bank ID:16189
UniProt:IL-4
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