Anti-Mouse IL-1R (CD121a) In Vivo Antibody - Low Endotoxin

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SKU:
IVMB0006
Product Type:
In Vivo Monoclonal Antibody
Clone:
JAMA-147
Protein:
Interleukin-1 R
Isotype:
Armenian Hamster IgG
Reactivity:
Mouse
Synonyms:
CD121a
Research Area:
Cytokines, Chemokines & Receptors
Endotoxin Level:
Low Endotoxin
Host Species:
Armenian Hamster
Applications:
Blocking
Applications:
IP
Applications:
WB

Description

system_update_altTechnical Datasheet
Product Name:Anti-Mouse IL-1R (CD121a) In Vivo Antibody - Low Endotoxin
Product Code:IVMB0006
Size:1mg, 5mg, 25mg, 50mg, 100mg
Clone:JAMA-147
Protein:Interleukin-1 R
Product Type:Monoclonal Antibody
Synonyms:CD121a
Isotype:Armenian Hamster IgG
Reactivity:Mouse
Immunogen:Extracellular domain of mouse IL-1 R type 1
Applications:B, IP, WB
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications:B, IP, WB
Reactivity:Mouse
Host Species:Armenian Hamster
Specificity:Armenian Hamster Anti-Mouse IL-1 R1 (Clone JAMA-147) recognizes Mouse IL-1 R1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Immunogen:Extracellular domain of mouse IL-1 R type 1
Concentration:≥ 5.0 mg/ml
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

IL-1 binds two receptors, IL-1RI and IL-1RII. The ligands IL-1α and IL-1β exert all of their various biological actions by binding IL-1RI. IL-1RII has a shortened cytoplasmic domain that is unable to transduce signals and therefore acts as a decoy receptor and competitively antagonizes the binding of IL-1α and IL-1β, thereby reducing their biological effects. Binding of the ligands to IL-1RI is enhanced by an accessory protein, IL-1R-AcP. IL-1RI is expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. It is an 80 kD transmembrane glycoprotein.

Technical Datasheet:View
Protein:Interleukin-1 R
Ligand/Receptor:IL-1α and IL-1β
Research Area:Immunology, Innate Immunity
Product Thumbnail
Armenian Hamster IgG Isotype Control
Clone PIP
Isotype Armenian Hamster IgG
Endotoxin Level Low Endotoxin
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