Product Name:	Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin
Product Code:	IVMB0073
Size:	1mg, 5mg, 25mg, 50mg, 100mg
Clone:	9D9
Protein:	CTLA-4
Product Type:	Monoclonal Antibody
Synonyms:	CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56
Isotype:	Mouse IgG2b
Reactivity:	Mouse
Immunogen:	Not Available
Applications:	FA, WB
Formulation:	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:	<0.5 EU/mg as determined by the LAL method
Purity:	≥98% monomer by analytical SEC >95% by SDS Page
Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Product Code	Product Name	Endotoxin Level
IVMB0072	Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Low Endotoxin	Low
IVMB0073	Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin	Ultra Low

Applications:	FA, WB
Reactivity:	Mouse

Host Species:	Mouse
Specificity:	Clone 9D9 recognizes an epitope on mouse CTLA-4.
Antigen Distribution:	CTLA-4 is expressed on activated T and B lymphocytes.
Immunogen:	Not Available
Concentration:	≥ 5.0 mg/ml
Endotoxin Level:	<0.5 EU/mg as determined by the LAL method
Purity:	≥98% monomer by analytical SEC >95% by SDS Page
Formulation:	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.

Technical Datasheet:	View
Protein:	CTLA-4
Function:	Negative regulator of T cell activation
Ligand/Receptor:	CD80 (B7.1), CD86 (B7.2)
Research Area:	Immunology, Inhibitory Molecules