Product Name:	Anti-Mouse CD278 (ICOS) In Vivo Antibody - Low Endotoxin
Product Code:	IVMB0082
Size:	1mg, 5mg, 25mg, 50mg, 100mg
Clone:	7E.17G9
Protein:	CD278
Product Type:	Monoclonal Antibody
Synonyms:	Inducible Costimulator, ICOS
Isotype:	Rat IgG2b κ
Reactivity:	Mouse
Immunogen:	Mouse ICOS cDNA and ICOS hexahistidine fusion protein
Applications:	B, FA, WB
Formulation:	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:	< 1.0 EU/mg as determined by the LAL method
Purity:	≥95% monomer by analytical SEC >95% by SDS Page
Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Product Code	Product Name	Endotoxin Level
IVMB0082	Anti-Mouse CD278 (ICOS) In Vivo Antibody - Low Endotoxin	Low
IVMB0083	Anti-Mouse CD278 (ICOS) In Vivo Antibody - Ultra Low Endotoxin	Ultra Low

Applications:	B, FA, WB
Reactivity:	Mouse

Host Species:	Rat
Specificity:	Clone 7E.17G9 recognizes an epitope on mouse CD278.
Antigen Distribution:	ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages.
Immunogen:	Mouse ICOS cDNA and ICOS hexahistidine fusion protein
Concentration:	≥ 5.0 mg/ml
Endotoxin Level:	< 1.0 EU/mg as determined by the LAL method
Purity:	≥95% monomer by analytical SEC >95% by SDS Page
Formulation:	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.

Technical Datasheet:	View
Protein:	CD278
Function:	Costimulates T cell activation, proliferation, humoral immune response
Ligand/Receptor:	B7h/B7RP-1/GL-50
Research Area:	Costimulatory Molecules, Immunology