Anti-Mouse CD172a - Purified Invivo Antibody

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SKU:
IVMB0286
Product Type:
In Vivo Monoclonal Antibody
Clone:
P84
Protein:
CD172a
Isotype:
IgG1 k
Reactivity:
Mouse
Synonyms:
SHPS-1
Synonyms:
BIT
Synonyms:
P84
Synonyms:
PTPNS1
Synonyms:
CD172 antigen-like family member A
Research Area:
Cell Adhesion
Research Area:
Innate Immunity
Research Area:
Neuroscience
Host Species:
Rat
Applications:
Blocking
Applications:
CyTOF
Applications:
FC
Applications:
IHC FF
Applications:
IP

Description

Product Name:Anti-Mouse CD172a - Purified Invivo Antibody
Product Code:IVMB0286
Clone:P84
Protein:CD172a
Product Type:Monoclonal Antibody
Synonyms:SHPS-1, BIT, P84, PTPNS1, CD172 antigen-like family member A
Isotype:IgG1 k
Reactivity:Mouse
Applications:B, CyTOF®, FC, IHC FF, IP
Formulation:This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Product Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Applications:B, CyTOF®, FC, IHC FF, IP
Reactivity:Mouse
Host Species:Rat
Specificity:Clone P84 recognizes an epitope on mouse CD172a.
Antigen Distribution:CD172a is expressed on monocytes, macrophages, dendritic cells, and neuronal cells.
Immunogen:Mouse brain membrane protein
Concentration:0.5 mg/ml
Formulation:This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:This purified antibody is stable when stored at 2-8°C. Do not freeze.

CD172a antibody, clone P84, recognizes CD172a, also known as single regulatory protein α (SIRPα) (signal regulatory protein alpha) or Src homology 2 domain-containing phosphatase substrate-1 (SHP-1), a type I transmembrane glycoprotein with three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibition motifs (ITIMs)1. SIRPα is expressed predominantly in myeloid cells2 - including monocytes, macrophages, and dendritic cells (DCs) - and neuronal cells3. The extracellular ligand for SIRPα, CD47 (or integrin-associated protein [IAP])4, is expressed in most cell types5. In macrophages, ligation of SIRPα by CD47 inhibits macrophage phagocytosis of self cells6,7. SIRPα also negatively regulates DC-mediated T cell activation and DC maturation8-10. CD47 is also upregulated on tumor cells, inhibiting the phagocytosis of tumor cells by macrophages11. Therapeutics targeting the CD47-SIRPα interaction, including antibodies and fusion proteins, are currently under preclinical and clinical study for various malignancies as a monotherapy or in combination with other therapeutics12.

Protein:CD172a
Function:Negative regulation of several biological processes
Ligand/Receptor:CD47, SP-A, SP-D
Research Area:Cell Adhesion, Innate Immunity, Neuroscience
Shipping:2-8°C
NCBI Gene Bank ID:16421
UniProt:CD172a
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