Epigenetics & Nuclear Signaling Antibodies 4
Anti-MORF4L2 Antibody (CAB7577)
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- SKU:
- CAB7577
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-MORF4L2 Antibody |
| Antibody SKU: | CAB7577 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MORF4L2 (NP_001135890.1). |
| Application: | IHC IF |
| Recommended Dilution: | IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MORF4L2 (NP_001135890.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSSR KQGS QPRG QQSA EEEN FKKP TRSN MQRS KMRG ASSG KKTA GPQQ KNLE PALP GRWG GRSA ENPP SGSV RKTR KNKQ KTPG NGDG GSTS EAPQ PPRK |
| Gene ID: | 9643 |
| Uniprot: | Q15014 |
| Cellular Location: | Nucleus |
| Calculated MW: | 32kDa |
| Observed MW: |
| Synonyms: | MORF4L2, MORFL2, MRGX |
| Background: |
| UniProt Protein Function: | MORF4L2: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: Xq22 Cellular Component: NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus; plasma membrane Molecular Function:protein binding Biological Process: chromatin remodeling; chromatin silencing; histone deacetylation |
| UniProt Code: | Q15014 |
| NCBI GenInfo Identifier: | 3123049 |
| NCBI Gene ID: | 9643 |
| NCBI Accession: | Q15014.1 |
| UniProt Secondary Accession: | Q15014,Q567V0, Q8J026, B3KP92, D3DXA5, |
| UniProt Related Accession: | Q15014 |
| Molecular Weight: | 32,308 Da |
| NCBI Full Name: | Mortality factor 4-like protein 2 |
| NCBI Synonym Full Names: | mortality factor 4 like 2 |
| NCBI Official Symbol: | MORF4L2 |
| NCBI Official Synonym Symbols: | MRGX; MORFL2 |
| NCBI Protein Information: | mortality factor 4-like protein 2 |
| UniProt Protein Name: | Mortality factor 4-like protein 2 |
| UniProt Synonym Protein Names: | MORF-related gene X protein; Protein MSL3-2; Transcription factor-like protein MRGX |
| Protein Family: | Mortality factor 4-like protein |
| UniProt Gene Name: | MORF4L2 |
| UniProt Entry Name: | MO4L2_HUMAN |
 | Immunofluorescence analysis of A549 cells using MORF4L2 antibody (CAB7577). |
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