Immunology Antibodies 1

Anti-MORC3 Antibody (CAB15414)

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SKU:
CAB15414
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-MORC3 Antibody
Antibody SKU:CAB15414
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 640-939 of human MORC3 (NP_056173.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 640-939 of human MORC3 (NP_056173.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TQTE VPSL VVKK EETV EDEI DVRN DAVI LPSC VEAE AKIH ETQE TTDK SADD AGCQ LQEL RNQL LLVT EEKE NYKR QCHM FTDQ IKVL QQRI LEMN DKYV KKET CHQS TETD AVFL LESI NGKS ESPD HMVS QYQQ ALEE IERL KKQC SALQ HVKA ECSQ CSNN ESKS EMDE MAVQ LDDV FRQL DKCS IERD QYKS EVEL LEME KSQI RSQC EELK TEVE QLKS TNQQ TATD VSTS SNIE ESVN HMDG ESLK LRSL RVNV GQLL AMIV PDLD LQQV NYDV DVVD EILG QVVE QMSE ISST
Gene ID:23515
Uniprot:Q14149
Cellular Location:
Calculated MW:107kDa
Observed MW:Refer to figures
Synonyms:MORC3, NXP2, ZCW5, ZCWCC3
Background:This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms.
UniProt Protein Function:MORC3: Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233). {ECO:0000269|PubMed:11927593, ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26202233}. Homodimer (PubMed:17332504). The sumoylated form interacts with PML (via SUMO-interacting motif) (PubMed:20501696, PubMed:17332504). Interacts with PT53 (PubMed:17332504). Interacts with influenza A virus PA and PB1 polymerase subunits during infection (PubMed:26202233). {ECO:0000269|PubMed:17332504, ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:26202233}
UniProt Protein Details:

Protein type:RNA-binding; Cell cycle regulation

Chromosomal Location of Human Ortholog: 21q22.13

Cellular Component: nucleoplasm; PML body

Biological Process: cell aging; maintenance of protein localization in nucleus; negative regulation of fibroblast proliferation; peptidyl-serine phosphorylation; protein amino acid phosphorylation; protein stabilization

NCBI Summary:This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
UniProt Code:Q14149
NCBI GenInfo Identifier:108935853
NCBI Gene ID:23515
NCBI Accession:Q14149.3
UniProt Secondary Accession:Q14149,Q9UEZ2, A8KA92,
UniProt Related Accession:Q14149
Molecular Weight:107,113 Da
NCBI Full Name:MORC family CW-type zinc finger protein 3
NCBI Synonym Full Names:MORC family CW-type zinc finger 3
NCBI Official Symbol:MORC3  
NCBI Official Synonym Symbols:NXP2; ZCW5; ZCWCC3  
NCBI Protein Information:MORC family CW-type zinc finger protein 3
UniProt Protein Name:MORC family CW-type zinc finger protein 3
UniProt Synonym Protein Names:Nuclear matrix protein 2
Protein Family:MORC family CW-type zinc finger protein
UniProt Gene Name:MORC3  
UniProt Entry Name:MORC3_HUMAN
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