Cell Biology Antibodies 13

Anti-MORC2 Antibody (CAB17641)

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SKU:
CAB17641
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MORC2 Antibody
Antibody SKU:CAB17641
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human MORC2 (NP_055756.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, 293T, Mouse thymus, Mouse testis, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human MORC2 (NP_055756.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EDTM TCLF LSRT FHEE EGID EVIV PLPT WNAR TREP VTDN VEKF AIET ELIY KYSP FRTE EEVM TQFM KIPG DSGT LVII FNLK LMDN GEPE LDII SNPR DIQM AETS PEGT KPER RSFR AYAA VLYI DPRM RIFI HGHK VQTK RLSC CLYK PRMY KYTS SRFK TRAE QEVK KAEH VARI AEEK AREA ESK
Gene ID:22880
Uniprot:Q9Y6X9
Cellular Location:
Calculated MW:
Observed MW:118kDa
Anti-MORC2 Antibody (CAB17641)Western blot - MORC2 Polyclonal Antibody (CAB17641)
Synonyms:CMT2Z, ZCW3, ZCWCC1, MORC2
Background:This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
UniProt Protein Function:MORC2: a protein containing a Zinc finger CW-type coiled-coil domain and a HATPase_c domain. HATPase_c domains are found in several ATP-binding proteins including histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, and DNA mismatch repair proteins.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: cytoplasm; nucleus

NCBI Summary:This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
UniProt Code:Q9Y6X9
NCBI GenInfo Identifier:114152840
NCBI Gene ID:22880
NCBI Accession:Q9Y6X9.2
UniProt Secondary Accession:Q9Y6X9,Q9UF28, Q9Y6V2, B2RNB1,
UniProt Related Accession:Q9Y6X9
Molecular Weight:110,724 Da
NCBI Full Name:MORC family CW-type zinc finger protein 2
NCBI Synonym Full Names:MORC family CW-type zinc finger 2
NCBI Official Symbol:MORC2  
NCBI Official Synonym Symbols:ZCW3; CMT2Z; ZCWCC1  
NCBI Protein Information:MORC family CW-type zinc finger protein 2
UniProt Protein Name:MORC family CW-type zinc finger protein 2
UniProt Synonym Protein Names:Zinc finger CW-type coiled-coil domain protein 1
Protein Family:MORC family CW-type zinc finger protein
UniProt Gene Name:MORC2  
UniProt Entry Name:MORC2_HUMAN
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