Cell Biology Antibodies 13

Anti-MonoMethyl-Histone H2B-K5 Antibody (CAB17552)

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SKU:
CAB17552
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MonoMethyl-Histone H2B-K5 Antibody
Antibody SKU:CAB17552
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of Human H2BK5me1.
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:C6
Immunogen:A synthetic peptide of Human H2BK5me1.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8349
Uniprot:Q16778
Cellular Location:Chromosome, Nucleus
Calculated MW:13kDa
Observed MW:14kDa
Anti-MonoMethyl-Histone H2B-K5 Antibody (CAB17552)Western blot - MonoMethyl-Histone H2B-K5 Rabbit pAb (CAB17552)
Synonyms:GL105, H2B, H2B.1, H2BFQ, H2BGL105, H2BQ, Histone H2B, HIST2H2BE
Background:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity. [provided by RefSeq, Aug 2015]
UniProt Protein Function:H2B2E: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2B family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 1q21.2

Cellular Component: nucleoplasm; extracellular space; nucleosome; nucleus

Molecular Function:DNA binding; protein heterodimerization activity

Biological Process: nucleosome assembly; defense response to Gram-positive bacterium; establishment and/or maintenance of chromatin architecture; innate immune response in mucosa; antibacterial humoral response

NCBI Summary:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. The protein has antibacterial and antifungal antimicrobial activity. [provided by RefSeq, Aug 2015]
UniProt Code:Q16778
NCBI GenInfo Identifier:7387736
NCBI Gene ID:8349
NCBI Accession:Q16778.3
UniProt Related Accession:Q16778
Molecular Weight:14kDa
NCBI Full Name:Histone H2B type 2-E
NCBI Synonym Full Names:H2B clustered histone 21
NCBI Official Symbol:H2BC21  
NCBI Official Synonym Symbols:H2B; H2BQ; GL105; H2B.1; H2BFQ; H2BGL105; HIST2H2BE  
NCBI Protein Information:histone H2B type 2-E
UniProt Protein Name:Histone H2B type 2-E
UniProt Synonym Protein Names:Histone H2B-GL105; Histone H2B.q; H2B/q
Protein Family:Histone
UniProt Gene Name:HIST2H2BE  
UniProt Entry Name:H2B2E_HUMAN
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