Cell Biology Antibodies 7
Anti-MOK Antibody (CAB1786)
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- SKU:
- CAB1786
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MOK Antibody |
| Antibody SKU: | CAB1786 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human MOK (NP_055041.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human MOK (NP_055041.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKNY KAIG KIGE GTFS EVMK MQSL RDGN YYAC KQMK QRFE SIEQ VNNL REIQ ALRR LNPH PNIL MLHE VVFD RKSG SLAL ICEL MDMN IYEL IRGR RYPL SEKK IMHY MYQL CKSL DHIH RNGI FHRD VKPE NILI KQDV LKLG DFGS CRSV YSKQ PYTE YIST RWYR APEC LLTD GFYT YKMD LWSA GCVF YEIA SLQP LFPG VNEL DQIS KIHD VIGT PAQK ILTK FK |
| Gene ID: | 5891 |
| Uniprot: | Q9UQ07 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 7kDa/10kDa/27kDa/44kDa/47kDa/48kDa |
| Observed MW: | 40kDa |
| Synonyms: | MOK, RAGE, RAGE-1, RAGE1, STK30 |
| Background: | This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. |
| UniProt Protein Function: | MOK: a CMGC protein kinase of the RCK family. Possesses a Thr-Glu-Tyr motif in the activation loop domain, as do classical MAP kinases. Associates with and is apparently stabilized by HSP90. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, CMGC; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); CMGC group; RCK family Chromosomal Location of Human Ortholog: 14q32 Cellular Component: cytoplasm Molecular Function:protein serine/threonine kinase activity; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity Biological Process: regulation of cell cycle; signal transduction; protein amino acid phosphorylation |
| NCBI Summary: | This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q9UQ07 |
| NCBI GenInfo Identifier: | 41017258 |
| NCBI Gene ID: | 5891 |
| NCBI Accession: | Q9UQ07.1 |
| UniProt Secondary Accession: | Q9UQ07,Q92790, Q93067, B2R6Z4, B7Z7P6, E7ER76, E7ERR8 |
| UniProt Related Accession: | Q9UQ07 |
| Molecular Weight: | 419 |
| NCBI Full Name: | MAPK/MAK/MRK overlapping kinase |
| NCBI Synonym Full Names: | MOK protein kinase |
| NCBI Official Symbol: | MOK |
| NCBI Official Synonym Symbols: | RAGE; RAGE1; STK30; RAGE-1 |
| NCBI Protein Information: | MAPK/MAK/MRK overlapping kinase; renal tumor antigen 1; renal cell carcinoma antigen |
| UniProt Protein Name: | MAPK/MAK/MRK overlapping kinase |
| UniProt Synonym Protein Names: | MOK protein kinase; Renal tumor antigen 1; RAGE-1 |
| Protein Family: | MAPK/MAK/MRK overlapping kinase |
| UniProt Gene Name: | MOK |
| UniProt Entry Name: | MOK_HUMAN |
 | Western blot analysis of extracts of mouse liver, using MOK antibody (CAB1786) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded mouse kidney using MOK antibody (CAB1786) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat heart using MOK antibody (CAB1786) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver using MOK antibody (CAB1786) at dilution of 1:100 (40x lens). |
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