Cell Biology Antibodies 9

Anti-MOG Antibody (CAB5353)

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SKU:
CAB5353
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MOG Antibody
Antibody SKU:CAB5353
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-154 of human MOG (NP_996532.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-154 of human MOG (NP_996532.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GQFR VIGP RHPI RALV GDEV ELPC RISP GKNA TGME VGWY RPPF SRVV HLYR NGKD QDGD QAPE YRGR TELL KDAI GEGK VTLR IRNV RFSD EGGF TCFF RDHS YQEE AAME LKVE DPFY WVSP G
Gene ID:4340
Uniprot:Q16653
Cellular Location:Cell membrane, Multi-pass membrane protein, Single-pass type I membrane protein
Calculated MW:12- 14kDa/19-33kDa
Observed MW:28kDa
Synonyms:MOG, BTN6, BTNL11, MOGIG2, NRCLP7
Background:The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
UniProt Protein Function:MOG: Mediates homophilic cell-cell adhesion. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7). Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Belongs to the immunoglobulin superfamily. BTN/MOG family. 10 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: integral to membrane; plasma membrane

Biological Process: central nervous system development; positive regulation of MyD88-dependent toll-like receptor signaling pathway; cell adhesion

Disease: Narcolepsy 7

NCBI Summary:The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q16653
NCBI GenInfo Identifier:317373391
NCBI Gene ID:4340
NCBI Accession:Q16653.2
UniProt Secondary Accession:Q16653,O00713, O00714, O00715, Q13054, Q13055, A6NDR4 A6NNJ9, A8MY31, B0UZR9, E9PGF0, F8W9D5,
UniProt Related Accession:Q16653
Molecular Weight:247
NCBI Full Name:Myelin-oligodendrocyte glycoprotein
NCBI Synonym Full Names:myelin oligodendrocyte glycoprotein
NCBI Official Symbol:MOG  
NCBI Official Synonym Symbols:BTN6; BTNL11; MOGIG2; NRCLP7  
NCBI Protein Information:myelin-oligodendrocyte glycoprotein; MOG Ig-AluB; MOG alpha-5
UniProt Protein Name:Myelin-oligodendrocyte glycoprotein
Protein Family:Molybdopterin adenylyltransferase
UniProt Gene Name:MOG  
UniProt Entry Name:MOG_HUMAN
Anti-MOG Antibody (CAB5353)Western blot analysis of extracts of mouse brain, using MOG antibody (CAB5353) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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