Cell Biology Antibodies 9
Anti-MOCS2 Antibody (CAB3965)
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- SKU:
- CAB3965
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MOCS2 Antibody |
| Antibody SKU: | CAB3965 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-188 of human MOCS2 (NP_004522.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-188 of human MOCS2 (NP_004522.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSSL EISS SCFS LETK LPLS PPLV EDSA FEPS RKDM DEVE EKSK DVIN FTAE KLSV DEVS QLVI SPLC GAIS LFVG TTRN NFEG KKVI SLEY EAYL PMAE NEVR KICS DIRQ KWPV KHIA VFHR LGLV PVSE ASII IAVS SAHR AASL EAVS YAID TLKA KVPI WKKE IYEE SSTW KGNK ECFW ASNS |
| Gene ID: | 4338 |
| Uniprot: | O96007/O96033 |
| Cellular Location: | Cytoplasm, cytosol |
| Calculated MW: | 9kDa |
| Observed MW: | 13kDa |
| Synonyms: | MOCS2, MCBPE, MOCO1, MOCODB, MPTS |
| Background: | Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. |
| UniProt Protein Function: | MOCS2: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group. Defects in MOCS2 are the cause of molybdenum cofactor deficiency type B (MOCOD type B). MOCOD type B is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death. Belongs to the MoaE family. MOCS2B subfamily. |
| UniProt Protein Details: | Protein type:Enzyme, misc.; EC 2.8.1.12 Chromosomal Location of Human Ortholog: 5q11 Cellular Component: cytoplasm; cytosol; molybdopterin synthase complex; nucleus Molecular Function:Mo-molybdopterin synthase activity Biological Process: Mo-molybdopterin cofactor biosynthetic process; molybdopterin cofactor biosynthetic process Disease: Molybdenum Cofactor Deficiency, Complementation Group B |
| NCBI Summary: | Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O96007 |
| NCBI GenInfo Identifier: | 20138899 |
| NCBI Gene ID: | 4338 |
| NCBI Accession: | O96007.1 |
| UniProt Secondary Accession: | O96007,Q6IAI3, |
| UniProt Related Accession: | O96007,O96033 |
| Molecular Weight: | 20,944 Da |
| NCBI Full Name: | Molybdopterin synthase catalytic subunit |
| NCBI Synonym Full Names: | molybdenum cofactor synthesis 2 |
| NCBI Official Symbol: | MOCS2 |
| NCBI Official Synonym Symbols: | MPTS; MCBPE; MOCO1; MOCODB |
| NCBI Protein Information: | molybdopterin synthase catalytic subunit; molybdopterin synthase sulfur carrier subunit |
| UniProt Protein Name: | Molybdopterin synthase catalytic subunit |
| UniProt Synonym Protein Names: | MOCO1-B; Molybdenum cofactor synthesis protein 2 large subunit |
| UniProt Gene Name: | MOCS2 |
| UniProt Entry Name: | MOC2B_HUMAN |
 | Western blot analysis of extracts of mouse kidney, using MOCS2 antibody (CAB3965) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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