Metabolism Antibodies 2

Anti-MOCS1 Antibody (CAB7701)

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SKU:
CAB7701
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-MOCS1 Antibody
Antibody SKU:CAB7701
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 90-360 of human MOCS1 (NP_005934.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 90-360 of human MOCS1 (NP_005934.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EEGV PLTP KANL LTTE EILT LARL FVKE GIDK IRLT GGEP LIRP DVVD IVAQ LQRL EGLR TIGV TTNG INLA RLLP QLQK AGLS AINI SLDT LVPA KFEF IVRR KGFH KVME GIHK AIEL GYNP VKVN CVVM RGLN EDEL LDFA ALTE GLPL DVRF IEYM PFDG NKWN FKKM VSYK EMLD TVRQ QWPE LEKV PEEE SSTA KAFK IPGF QGQI SFIT SMSE HFCG TCNR LRIT ADGN LKVC LFGN SEVS LRDH LRAG ASEQ ELLR IIGA AVG
Gene ID:4337
Uniprot:Q9NZB8
Cellular Location:
Calculated MW:31kDa/40kDa/43kDa/58kDa/68kDa/70kDa
Observed MW:Refer to figures
Synonyms:MOCS1, MIG11, MOCOD, MOCODA
Background:Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants, whose full-length natures have yet to be determined, are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related pseudogene has been identified on chromosome 16.
UniProt Protein Function:MOCS1: Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of a guanosine derivative to precursor Z during molybdenum cofactor biosynthesis. Defects in MOCS1 are the cause of molybdenum cofactor deficiency type A (MOCOD type A); an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death. 8 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Enzyme, misc.; EC 4.1.99.18

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cytosol

Biological Process: Mo-molybdopterin cofactor biosynthetic process; molybdopterin cofactor biosynthetic process

Disease: Molybdenum Cofactor Deficiency, Complementation Group A

NCBI Summary:Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants, whose full-length natures have yet to be determined, are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related pseudogene has been identified on chromosome 16. [provided by RefSeq, Jan 2010]
UniProt Code:Q9NZB8
NCBI GenInfo Identifier:30913216
NCBI Gene ID:4337
NCBI Accession:Q9NZB8.3
UniProt Secondary Accession:Q9NZB8,O14940, O14941, O75710, Q5J7W0, Q5TCE1, Q5TCE2 Q5TCE6, Q5TCE9, Q5TCF0, B3KPT7, B4DTP1,
UniProt Related Accession:Q9NZB8
Molecular Weight:70,167 Da
NCBI Full Name:Molybdenum cofactor biosynthesis protein 1
NCBI Synonym Full Names:molybdenum cofactor synthesis 1
NCBI Official Symbol:MOCS1  
NCBI Official Synonym Symbols:MIG11; MOCOD; MOCODA  
NCBI Protein Information:molybdenum cofactor biosynthesis protein 1
UniProt Protein Name:Molybdenum cofactor biosynthesis protein 1
UniProt Synonym Protein Names:Cell migration-inducing gene 11 protein; Molybdenum cofactor synthesis-step 1 protein A-BIncluding the following 2 domains:Cyclic pyranopterin monophosphate synthase (EC:4.1.99.18)Alternative name(s):Molybdenum cofactor biosynthesis protein A
UniProt Gene Name:MOCS1  
UniProt Entry Name:MOCS1_HUMAN
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