Epigenetics & Nuclear Signaling Antibodies 3
Anti-MMS19 Antibody (CAB4922)
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- SKU:
- CAB4922
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MMS19
- Synonyms:
- MET18
- Synonyms:
- MMS19L
- Synonyms:
- hMMS19
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | MMS19 Rabbit pAb |
| Product Code: | CAB4922 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | MMS19, MET18, MMS19L, hMMS19 |
| Applications: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 761-1030 of human MMS19 (NP_071757.4). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:200 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 761-1030 of human MMS19 (NP_071757.4). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FAGL LNKH PAGQ QLDE FLQL AVDK VEAG LGSG PCRS QAFT LLLW VTKA LVLR YHPL SSCL TARL MGLL SDPE LGPA AADG FSLL MSDC TDVL TRAG HAEV RIMF RQRF FTDN VPAL VQGF HAAP QDVK PNYL KGLS HVLN RLPK PVLL PELP TLLS LLLE ALSC PDCV VQLS TLSC LQPL LLEA PQVM SLHV DTLV TKFL NLSS SPSM AVRI AALQ CMHA LTRL PTPV LLPY KPQV IRAL AKPL DDKK RLVR KEAV SARG EWFL LGSP GS |
| Gene ID: | 64210 |
| Uniprot: | Q96T76 |
| Cellular Location: | Cytoplasm, Nucleus, cytoskeleton, spindle |
| Calculated MW: | 3kDa/35kDa/102kDa/108kDa/113kDa/115kDa |
| Observed MW: | 113kDa |
| UniProt Protein Function: | MMS19: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. Belongs to the MET18/MMS19 family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 10q24-q25 Cellular Component: nucleoplasm; holo TFIIH complex; membrane; cytoplasm; spindle; nucleus Molecular Function:protein binding, bridging; protein binding; receptor signaling complex scaffold activity; transcription coactivator activity; estrogen receptor binding Biological Process: transcription, DNA-dependent; nucleotide-excision repair; iron-sulfur cluster assembly; positive regulation of transcription, DNA-dependent; response to hormone stimulus; two-component signal transduction system (phosphorelay); DNA repair; response to DNA damage stimulus; DNA metabolic process; chromosome segregation |
| UniProt Code: | Q96T76 |
| NCBI GenInfo Identifier: | 150421597 |
| NCBI Gene ID: | 64210 |
| NCBI Accession: | Q96T76.2 |
| UniProt Related Accession: | Q96T76 |
| Molecular Weight: | |
| NCBI Full Name: | MMS19 nucleotide excision repair protein homolog |
| NCBI Synonym Full Names: | MMS19 homolog, cytosolic iron-sulfur assembly component |
| NCBI Official Symbol: | MMS19 |
| NCBI Official Synonym Symbols: | CIAO4; MET18; MMS19L; hMMS19 |
| NCBI Protein Information: | MMS19 nucleotide excision repair protein homolog |
| UniProt Protein Name: | MMS19 nucleotide excision repair protein homolog |
| UniProt Synonym Protein Names: | MET18 homolog; MMS19-like protein |
| Protein Family: | MMS19 nucleotide excision repair protein |
| UniProt Gene Name: | MMS19 |
| UniProt Entry Name: | MMS19_HUMAN |
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