Epigenetics & Nuclear Signaling Antibodies 3

Anti-MMS19 Antibody (CAB4922)

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SKU:
CAB4922
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MMS19
Synonyms:
MET18
Synonyms:
MMS19L
Synonyms:
hMMS19
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:MMS19 Rabbit pAb
Product Code:CAB4922
Size:20uL, 50uL, 100uL
Synonyms:MMS19, MET18, MMS19L, hMMS19
Applications:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 761-1030 of human MMS19 (NP_071757.4).
Applications:WB
Recommended Dilutions:WB 1:200 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 761-1030 of human MMS19 (NP_071757.4).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FAGL LNKH PAGQ QLDE FLQL AVDK VEAG LGSG PCRS QAFT LLLW VTKA LVLR YHPL SSCL TARL MGLL SDPE LGPA AADG FSLL MSDC TDVL TRAG HAEV RIMF RQRF FTDN VPAL VQGF HAAP QDVK PNYL KGLS HVLN RLPK PVLL PELP TLLS LLLE ALSC PDCV VQLS TLSC LQPL LLEA PQVM SLHV DTLV TKFL NLSS SPSM AVRI AALQ CMHA LTRL PTPV LLPY KPQV IRAL AKPL DDKK RLVR KEAV SARG EWFL LGSP GS
Gene ID:64210
Uniprot:Q96T76
Cellular Location:Cytoplasm, Nucleus, cytoskeleton, spindle
Calculated MW:3kDa/35kDa/102kDa/108kDa/113kDa/115kDa
Observed MW:113kDa
UniProt Protein Function:MMS19: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. Belongs to the MET18/MMS19 family. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 10q24-q25

Cellular Component: nucleoplasm; holo TFIIH complex; membrane; cytoplasm; spindle; nucleus

Molecular Function:protein binding, bridging; protein binding; receptor signaling complex scaffold activity; transcription coactivator activity; estrogen receptor binding

Biological Process: transcription, DNA-dependent; nucleotide-excision repair; iron-sulfur cluster assembly; positive regulation of transcription, DNA-dependent; response to hormone stimulus; two-component signal transduction system (phosphorelay); DNA repair; response to DNA damage stimulus; DNA metabolic process; chromosome segregation

UniProt Code:Q96T76
NCBI GenInfo Identifier:150421597
NCBI Gene ID:64210
NCBI Accession:Q96T76.2
UniProt Related Accession:Q96T76
Molecular Weight:
NCBI Full Name:MMS19 nucleotide excision repair protein homolog
NCBI Synonym Full Names:MMS19 homolog, cytosolic iron-sulfur assembly component
NCBI Official Symbol:MMS19  
NCBI Official Synonym Symbols:CIAO4; MET18; MMS19L; hMMS19  
NCBI Protein Information:MMS19 nucleotide excision repair protein homolog
UniProt Protein Name:MMS19 nucleotide excision repair protein homolog
UniProt Synonym Protein Names:MET18 homolog; MMS19-like protein
Protein Family:MMS19 nucleotide excision repair protein
UniProt Gene Name:MMS19  
UniProt Entry Name:MMS19_HUMAN
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