Cell Biology Antibodies 6
Anti-MMP26 Antibody (CAB16135)
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- SKU:
- CAB16135
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MMP26 Antibody |
| Antibody SKU: | CAB16135 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-261 of human MMP26 (NP_068573.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-261 of human MMP26 (NP_068573.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TSIS PGRC KWNK HTLT YRII NYPH DMKP SAVK DSIY NAVS IWSN VTPL IFQQ VQNG DADI KVSF WQWA HEDG WPFD GPGG ILGH AFLP NSGN PGVV HFDK NEHW SASD TGYN LFLV ATHE IGHS LGLQ HSGN QSSI MYPT YWYH DPRT FQLS ADDI QRIQ HLYG EKCS SDIP |
| Gene ID: | 56547 |
| Uniprot: | Q9NRE1 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 29kDa |
| Observed MW: | 20kDa |
| Synonyms: | MMP26 |
| Background: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. |
| UniProt Protein Function: | MMP26: May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B. Belongs to the peptidase M10A family. |
| UniProt Protein Details: | Protein type:Protease; Secreted, signal peptide; Secreted; EC 3.4.24.- Chromosomal Location of Human Ortholog: 11p15 Cellular Component: proteinaceous extracellular matrix Molecular Function:zinc ion binding; metalloendopeptidase activity Biological Process: collagen catabolic process; proteolysis |
| NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, alpha 1-antitrypsin, alpha 2-macroglobulin, and insulin-like growth factor-binding protein 1, and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NRE1 |
| NCBI GenInfo Identifier: | 73808266 |
| NCBI Gene ID: | 56547 |
| NCBI Accession: | NP_068573.2 |
| UniProt Secondary Accession: | Q9NRE1,Q3MJ78, Q9GZS2, Q9NR87, |
| UniProt Related Accession: | Q9NRE1 |
| Molecular Weight: | 29,708 Da |
| NCBI Full Name: | matrix metalloproteinase-26 preproprotein |
| NCBI Synonym Full Names: | matrix metallopeptidase 26 |
| NCBI Official Symbol: | MMP26 |
| NCBI Protein Information: | matrix metalloproteinase-26 |
| UniProt Protein Name: | Matrix metalloproteinase-26 |
| UniProt Synonym Protein Names: | Endometase; Matrilysin-2 |
| Protein Family: | Matrix metalloproteinase |
| UniProt Gene Name: | MMP26 |
| UniProt Entry Name: | MMP26_HUMAN |
 | Western blot analysis of extracts of mouse kidney, using MMP26 antibody (CAB16135) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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