Cell Biology Antibodies 8
Anti-MMP17 Antibody (CAB3030)
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- SKU:
- CAB3030
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MMP17 Antibody |
| Antibody SKU: | CAB3030 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human MMP17 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, RAW264.7, Mouse testis, Rat testis |
| Immunogen: | A synthetic peptide of human MMP17 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4326 |
| Uniprot: | Q9ULZ9 |
| Cellular Location: | Cell membrane, Extracellular side, GPI-anchor, Lipid-anchor, Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 57kDa/66kDa |
| Observed MW: | 75kDa |
| Synonyms: | MMP17, MMP-17, MT4-MMP, MT4MMP, MTMMP4 |
| Background: | This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. |
| UniProt Protein Function: | MMP17: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. Belongs to the peptidase M10A family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Activator; EC 3.4.24.-; Membrane protein, integral; Membrane protein, GPI anchor; Protease Chromosomal Location of Human Ortholog: 12q24.3 Cellular Component: integral to plasma membrane Molecular Function:enzyme activator activity |
| NCBI Summary: | This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q9ULZ9 |
| NCBI GenInfo Identifier: | 296439485 |
| NCBI Gene ID: | 4326 |
| NCBI Accession: | Q9ULZ9.4 |
| UniProt Secondary Accession: | Q9ULZ9,Q14850, |
| UniProt Related Accession: | Q9ULZ9 |
| Molecular Weight: | 57,938 Da |
| NCBI Full Name: | Matrix metalloproteinase-17 |
| NCBI Synonym Full Names: | matrix metallopeptidase 17 |
| NCBI Official Symbol: | MMP17 |
| NCBI Official Synonym Symbols: | MMP-17; MT4MMP; MTMMP4; MT4-MMP |
| NCBI Protein Information: | matrix metalloproteinase-17 |
| UniProt Protein Name: | Matrix metalloproteinase-17 |
| UniProt Synonym Protein Names: | Membrane-type matrix metalloproteinase 4; MT-MMP 4; MTMMP4; Membrane-type-4 matrix metalloproteinase; MT4-MMP; MT4MMP |
| Protein Family: | Matrix metalloproteinase |
| UniProt Gene Name: | MMP17 |
| UniProt Entry Name: | MMP17_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MMP17 Rabbit pAb (CAB3030) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded Human colon using MMP17 Rabbit pAb (CAB3030) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Mouse brain using MMP17 Rabbit pAb (CAB3030) at dilution of 1:100 (40x lens). |
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