Cell Biology Antibodies 8
Anti-MMP10 Antibody (CAB3033)
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- SKU:
- CAB3033
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MMP10 Antibody |
| Antibody SKU: | CAB3033 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human MMP10 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, MCF7, U-251MG, M21 |
| Immunogen: | A synthetic peptide of human MMP10 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4319 |
| Uniprot: | P09238 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 54kDa |
| Observed MW: | 54kDa |
| Synonyms: | MMP10, SL-2, STMY2, stromelysin-2, MMP10 |
| Background: | This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. |
| UniProt Protein Function: | MMP10: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase. Belongs to the peptidase M10A family. |
| UniProt Protein Details: | Protein type:EC 3.4.24.22; Secreted; Protease; Extracellular matrix; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q22.3 Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region Molecular Function:zinc ion binding; metalloendopeptidase activity; calcium ion binding Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis; regulation of cell migration |
| NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09238 |
| NCBI GenInfo Identifier: | 116869 |
| NCBI Gene ID: | 4319 |
| NCBI Accession: | P09238.1 |
| UniProt Secondary Accession: | P09238,Q53HH9, B2R9X9, |
| UniProt Related Accession: | P09238 |
| Molecular Weight: | 476 |
| NCBI Full Name: | Stromelysin-2 |
| NCBI Synonym Full Names: | matrix metallopeptidase 10 (stromelysin 2) |
| NCBI Official Symbol: | MMP10 |
| NCBI Official Synonym Symbols: | SL-2; STMY2 |
| NCBI Protein Information: | stromelysin-2; MMP-10; transin 2; transin-2; stromelysin 2; matrix metalloprotease 10; matrix metalloproteinase-10; matrix metalloproteinase 10 (stromelysin 2) |
| UniProt Protein Name: | Stromelysin-2 |
| UniProt Synonym Protein Names: | Matrix metalloproteinase-10; MMP-10; Transin-2 |
| Protein Family: | Stromelysin |
| UniProt Gene Name: | MMP10 |
| UniProt Entry Name: | MMP10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MMP10 antibody (CAB3033) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded rat kidney using MMP10 antibody (CAB3033) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using MMP10 antibody (CAB3033) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of NIH-3T3 cells using MMP10 Polyclonal Antibody (CAB3033) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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