Cell Biology Antibodies 2
Anti-MMP1 Antibody (CAB1191)
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- SKU:
- CAB1191
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MMP1 Antibody |
| Antibody SKU: | CAB1191 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human MMP1 (NP_002412.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | SKOV3, HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-280 of human MMP1 (NP_002412.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FPAT LETQ EQDV DLVQ KYLE KYYN LKND GRQV EKRR NSGP VVEK LKQM QEFF GLKV TGKP DAET LKVM KQPR CGVP DVAQ FVLT EGNP RWEQ THLT YRIE NYTP DLPR ADVD HAIE KAFQ LWSN VTPL TFTK VSEG QADI MISF VRGD HRDN SPFD GPGG NLAH AFQP GPGI GGDA HFDE DERW TNNF REYN LHRV AAHE LGHS LGLS HSTD IGAL MYPS YTFS GDVQ LAQD DIDG IQAI YGRS QNPV QPIG PQTP KACD S |
| Gene ID: | 4312 |
| Uniprot: | P03956 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 54kDa |
| Observed MW: | 54kDa |
| Synonyms: | MMP1, CLG, CLGN |
| Background: | This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
| UniProt Protein Function: | MMP1: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. Belongs to the peptidase M10A family. |
| UniProt Protein Details: | Protein type:EC 3.4.24.7; Protease; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 11q22.3 Cellular Component: extracellular region Molecular Function:endopeptidase activity; metalloendopeptidase activity; serine-type endopeptidase activity Biological Process: cellular protein metabolic process; collagen catabolic process; extracellular matrix disassembly; leukocyte migration; positive regulation of protein oligomerization; proteolysis Disease: Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Pulmonary Disease, Chronic Obstructive |
| NCBI Summary: | This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P03956 |
| NCBI GenInfo Identifier: | 116852 |
| NCBI Gene ID: | 4312 |
| NCBI Accession: | P03956.3 |
| UniProt Secondary Accession: | P03956,P08156, |
| UniProt Related Accession: | P03956 |
| Molecular Weight: | 54,007 Da |
| NCBI Full Name: | Interstitial collagenase |
| NCBI Synonym Full Names: | matrix metallopeptidase 1 |
| NCBI Official Symbol: | MMP1 |
| NCBI Official Synonym Symbols: | CLG; CLGN |
| NCBI Protein Information: | interstitial collagenase |
| UniProt Protein Name: | Interstitial collagenase |
| UniProt Synonym Protein Names: | Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1 |
| Protein Family: | Interstitial collagenase |
| UniProt Gene Name: | MMP1 |
| UniProt Entry Name: | MMP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MMP1 antibody (CAB1191) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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