Cell Biology Antibodies 15
Anti-MLYCD Antibody (CAB18606)
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- SKU:
- CAB18606
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MLYCD Antibody |
| Antibody SKU: | CAB18606 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human MLYCD. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human MLYCD. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 23417 |
| Uniprot: | O95822 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | |
| Background: |
| UniProt Protein Function: | MLYCD: Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Defects in MLYCD are the cause of malonyl-CoA decarboxylase deficiency (MLYCD deficiency). MLYCD deficiency is an autosomal recessive disease characterized by abdominal pain, chronic constipation, episodic vomiting, metabolic acidosis and malonic aciduria. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - propanoate; Other Amino Acids Metabolism - beta-alanine; Lyase; EC 4.1.1.9 Chromosomal Location of Human Ortholog: 16q24 Cellular Component: peroxisomal matrix; mitochondrion; mitochondrial matrix; cytoplasm; peroxisome Molecular Function:malonyl-CoA decarboxylase activity; receptor binding Biological Process: positive regulation of fatty acid oxidation; acetyl-CoA biosynthetic process; cellular lipid metabolic process; fatty acid biosynthetic process Disease: Malonyl-coa Decarboxylase Deficiency |
| NCBI Summary: | The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95822 |
| NCBI GenInfo Identifier: | 110349750 |
| NCBI Gene ID: | 23417 |
| NCBI Accession: | NP_036345 |
| UniProt Secondary Accession: | O95822,Q9UNU5, Q9Y3F2, |
| UniProt Related Accession: | O95822 |
| Molecular Weight: | 50,946 Da |
| NCBI Full Name: | malonyl-CoA decarboxylase, mitochondrial |
| NCBI Synonym Full Names: | malonyl-CoA decarboxylase |
| NCBI Official Symbol: | MLYCD |
| NCBI Official Synonym Symbols: | MCD |
| NCBI Protein Information: | malonyl-CoA decarboxylase, mitochondrial |
| UniProt Protein Name: | Malonyl-CoA decarboxylase, mitochondrial |
| Protein Family: | (2S)-methylsuccinyl-CoA dehydrogenase |
| UniProt Gene Name: | MLYCD |
| UniProt Entry Name: | DCMC_HUMAN |
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