| UniProt Protein Function: | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. |
| UniProt Protein Details: | |
| NCBI Summary: | The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UH92 |
| NCBI GenInfo Identifier: | 20138856 |
| NCBI Gene ID: | 6945 |
| NCBI Accession: | Q9UH92.2 |
| UniProt Secondary Accession: | Q9UH92,Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3 A8K2J3, B2RAV8, B2RD73 |
| UniProt Related Accession: | Q9UH92 |
| Molecular Weight: | 27,883 Da |
| NCBI Full Name: | Max-like protein X |
| NCBI Synonym Full Names: | MLX, MAX dimerization protein |
| NCBI Official Symbol: | MLX |
| NCBI Official Synonym Symbols: | MAD7; MXD7; TCFL4; bHLHd13 |
| NCBI Protein Information: | max-like protein X |
| UniProt Protein Name: | Max-like protein X |
| UniProt Synonym Protein Names: | Class D basic helix-loop-helix protein 13; bHLHd13; Max-like bHLHZip protein; Protein BigMax; Transcription factor-like protein 4 |
| Protein Family: | Max-like protein |
| UniProt Gene Name: | MLX |
| UniProt Entry Name: | MLX_HUMAN |
