Cell Biology Antibodies 16
Anti-MLKL Antibody (CAB13452)
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- SKU:
- CAB13452
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MLKL Antibody |
| Antibody SKU: | CAB13452 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of mouse MLKL (NP_001297542.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of mouse MLKL (NP_001297542.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EGCD SKKI RELV AEDK KQEP VGQD CPEL LREI INEC RAHE PSQR PSVD GRSL SGRE RILE RLSA VEES TDKK V |
| Gene ID: | 74568 |
| Uniprot: | |
| Cellular Location: | Cell membrane, Cytoplasm |
| Calculated MW: | 53kDa/54kDa |
| Observed MW: | Refer to figures |
| Synonyms: | MLKL, hMLKL |
| Background: | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. |
 | Immunohistochemistry of paraffin-embedded human tonsil using MLKL antibody (CAB13452) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human breast cancer using MLKL antibody (CAB13452) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human uterine cancer using MLKL antibody (CAB13452) at dilution of 1:100 (40x lens). |
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