Cell Death Antibodies 1

Anti-MLKL Antibody (CAB11458)

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SKU:
CAB11458
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death

Description

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Antibody Name:Anti-MLKL Antibody
Antibody SKU:CAB11458
Antibody Size:20uL, 50uL, 100uL
Application:IHC IF
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human MLKL
Application:IHC IF
Recommended Dilution:IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human MLKL
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:197259
Uniprot:Q8NB16
Cellular Location:Cell membrane, Cytoplasm
Calculated MW:30kDa/54kDa
Observed MW:Refer to figures
Synonyms:hMLKL, MLKL
Background:This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
UniProt Protein Function:MLKL: Belongs to the protein kinase superfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; TKL-Unique family

Chromosomal Location of Human Ortholog: 16q23.1

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function:ATP binding; protein binding; protein complex binding; protein kinase activity; signal transducer activity

Biological Process: protein amino acid phosphorylation

NCBI Summary:This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
UniProt Code:Q8NB16
NCBI GenInfo Identifier:74762545
NCBI Gene ID:197259
NCBI Accession:Q8NB16.1
UniProt Secondary Accession:Q8NB16,Q8N6V0, A6NCE4,
UniProt Related Accession:Q8NB16
Molecular Weight:54kDa
NCBI Full Name:Mixed lineage kinase domain-like protein
NCBI Synonym Full Names:mixed lineage kinase domain like pseudokinase
NCBI Official Symbol:MLKL  
NCBI Official Synonym Symbols:hMLKL  
NCBI Protein Information:mixed lineage kinase domain-like protein
UniProt Protein Name:Mixed lineage kinase domain-like protein
UniProt Gene Name:MLKL  
Anti-MLKL Antibody (CAB11458)Immunohistochemistry of paraffin-embedded human tonsil using MLKL antibody (CAB11458) at dilution of 1:100 (40x lens).
Anti-MLKL Antibody (CAB11458)Immunofluorescence analysis of HeLa cells using MLKL Monoclonal Antibody (CAB11458) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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