Cell Cycle Antibodies 2
Anti-MLH1 Antibody (CAB4858)
- SKU:
- CAB4858
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- COCA2
- Synonyms:
- FCC2
- Synonyms:
- HNPCC
- Synonyms:
- HNPCC2
- Synonyms:
- hMLH1
- Research Area:
- Cell Cycle
Description
| Product Name: | MLH1 Rabbit mAb |
| Product Code: | CAB4858 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | COCA2, FCC2, HNPCC, HNPCC2, hMLH1 |
| Applications: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human MLH1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Jurkat, Mouse thymus |
| Immunogen: | A synthesized peptide derived from human MLH1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4292 |
| Uniprot: | P40692 |
| Cellular Location: | Nucleus |
| Calculated MW: | 85kDa |
| Observed MW: | 85KDa |
| UniProt Protein Function: | MLH1: a protein involved in the repair of mismatches in DNA. Binds PMS2 or MLH1 and MLH3. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50- MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with MBD4. Interacts with EXO1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2; Turcot syndrome, an autosomal dominant disorder characterized by malignant tumors of the brain; Muir-Torre syndrome (MTS), a rare autosomal dominant disorder characterized by sebaceous neoplasms and visceral malignancy; lobular carcinoma in situ; endometrial cancer; and non-polyposis colorectal cancer. |
| UniProt Protein Details: | Protein type:Tumor suppressor; DNA repair, damage Chromosomal Location of Human Ortholog: 3p21.3 Cellular Component: chiasma; membrane; MutLalpha complex; nucleoplasm; nucleus; synaptonemal complex Molecular Function:ATPase activity; MutSalpha complex binding; protein binding; single-stranded DNA binding Biological Process: mismatch repair; somatic hypermutation of immunoglobulin genes Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 2; Mismatch Repair Cancer Syndrome; Muir-torre Syndrome |
| NCBI Summary: | This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009] |
| UniProt Code: | P40692 |
| NCBI GenInfo Identifier: | 730028 |
| NCBI Gene ID: | 4292 |
| NCBI Accession: | P40692.1 |
| UniProt Secondary Accession: | P40692,B4DI13, B4DQ11, E9PCU2, |
| UniProt Related Accession: | P40692 |
| Molecular Weight: | 73,837 Da |
| NCBI Full Name: | DNA mismatch repair protein Mlh1 |
| NCBI Synonym Full Names: | mutL homolog 1 |
| NCBI Official Symbol: | MLH1 |
| NCBI Official Synonym Symbols: | FCC2; COCA2; HNPCC; hMLH1; HNPCC2 |
| NCBI Protein Information: | DNA mismatch repair protein Mlh1 |
| UniProt Protein Name: | DNA mismatch repair protein Mlh1 |
| UniProt Synonym Protein Names: | MutL protein homolog 1 |
| Protein Family: | Putative MutL protein |
| UniProt Gene Name: | MLH1 |
| UniProt Entry Name: | MLH1_HUMAN |
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