Cell Biology Antibodies 10
Anti-MLANA Antibody (CAB6290)
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- SKU:
- CAB6290
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MLANA Antibody |
| Antibody SKU: | CAB6290 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 48-118 of human MLANA (NP_005502.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | M21, Mouse eye, Rat eye |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 48-118 of human MLANA (NP_005502.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | CRRR NGYR ALMD KSLH VGTQ CALT RRCP QEGF DHRD SKVS LQEK NCEP VVPN APPA YEKL SAEQ SPPP YSP |
| Gene ID: | 2315 |
| Uniprot: | Q16655 |
| Cellular Location: | Endoplasmic reticulum membrane, Golgi apparatus, Melanosome, Single-pass type III membrane protein, trans-Golgi network membrane |
| Calculated MW: | 13kDa |
| Observed MW: | 18kDa |
| Synonyms: | MLANA, MART-1, MART1, melan-A |
| Background: |
| UniProt Protein Function: | MLANA: Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell surface Chromosomal Location of Human Ortholog: 9p24.1 Cellular Component: endoplasmic reticulum membrane; Golgi apparatus; integral to plasma membrane; melanosome; trans-Golgi network Molecular Function:protein binding |
| UniProt Code: | Q16655 |
| NCBI GenInfo Identifier: | 2833278 |
| NCBI Gene ID: | 2315 |
| NCBI Accession: | Q16655.1 |
| UniProt Secondary Accession: | Q16655,Q6ICU4, |
| UniProt Related Accession: | Q16655 |
| Molecular Weight: | 13,157 Da |
| NCBI Full Name: | Melanoma antigen recognized by T-cells 1 |
| NCBI Synonym Full Names: | melan-A |
| NCBI Official Symbol: | MLANA |
| NCBI Official Synonym Symbols: | MART1; MART-1 |
| NCBI Protein Information: | melanoma antigen recognized by T-cells 1 |
| UniProt Protein Name: | Melanoma antigen recognized by T-cells 1 |
| UniProt Synonym Protein Names: | Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A |
| Protein Family: | Melanoma antigen recognized by T-cells |
| UniProt Gene Name: | MLANA |
| UniProt Entry Name: | MAR1_HUMAN |
 | Western blot analysis of extracts of M21 cells, using MLANA antibody (CAB6290) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (RM00020)._Exposure time: 90s. |
 | Western blot analysis of extracts of various cell lines, using MLANA antibody (CAB6290) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s. |
 | Immunofluorescence analysis of U2OS cells using MLANA antibody (CAB6290). Blue: DAPI for nuclear staining. |
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