Signal Transduction Antibodies 2

Anti-MKRN3 Antibody (CAB16073)

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SKU:
CAB16073
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-MKRN3 Antibody
Antibody SKU:CAB16073
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MKRN3 (NP_005655.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MKRN3 (NP_005655.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEEP AAPS EAHE AAGA QAGA EAAR EGVS GPDL PVCE PSGE SAAP DSAL PHAA RGWA PFPV APVP AHLR RGGL RPAP ASGG GAWP SPLP SRSS GIWT KQII CRYY IHGQ CKEG ENCR YSHD LSGR KMAT EGGV SPPG ASAG GGPS TAAH IEPP TQEV AEAP PAAS SLSL PVIG SAAE RGFF EAER DNAD RGAA GGAG VESW ADAI EFVP GQPY RGRW VASA PEAP LQSS ETER KQMA VGSG LRFC YYAS RGVC FRGE SCMY
Gene ID:7681
Uniprot:Q13064
Cellular Location:
Calculated MW:55kDa
Observed MW:56kDa
Synonyms:MKRN3, CPPB2, D15S9, RNF63, ZFP127, ZNF127
Background:The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene.
UniProt Protein Function:MKRN3: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
UniProt Protein Details:

Protein type:EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 15q11.2

Cellular Component: intracellular ribonucleoprotein complex

Molecular Function:identical protein binding; metal ion binding; protein binding; transferase activity

Biological Process: protein ubiquitination

Disease: Prader-willi Syndrome; Precocious Puberty, Central, 2

NCBI Summary:The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q13064
NCBI GenInfo Identifier:5032243
NCBI Gene ID:7681
NCBI Accession:NP_005655.1
UniProt Related Accession:Q13064
Molecular Weight:55,645 Da
NCBI Full Name:probable E3 ubiquitin-protein ligase makorin-3
NCBI Synonym Full Names:makorin ring finger protein 3
NCBI Official Symbol:MKRN3  
NCBI Official Synonym Symbols:CPPB2; D15S9; RNF63; ZFP127; ZNF127  
NCBI Protein Information:probable E3 ubiquitin-protein ligase makorin-3
UniProt Protein Name:Probable E3 ubiquitin-protein ligase makorin-3
UniProt Synonym Protein Names:RING finger protein 63; RING-type E3 ubiquitin transferase makorin-3Curated; Zinc finger protein 127
Protein Family:Probable E3 ubiquitin-protein ligase makorin
UniProt Gene Name:MKRN3  
Anti-MKRN3 Antibody (CAB16073)Western blot analysis of extracts of mouse kidney, using MKRN3 antibody (CAB16073) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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