Cell Cycle Antibodies 1

Anti-MKI67 Antibody (CAB17341)

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SKU:
CAB17341
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-MKI67 Antibody
Antibody SKU:CAB17341
Antibody Size:20uL, 50uL, 100uL
Application:IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human MKI67
Application:IF
Recommended Dilution:IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant protein of human MKI67
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4288
Uniprot:P46013
Cellular Location:Chromosome, Nucleus, nucleolus
Calculated MW:319kDa/358kDa
Observed MW:Refer to figures
Synonyms:MKI67, KIA, MIB-, MIB-1, PPP1R105, marker of proliferation Ki-67, Ki67
Background:This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X.
UniProt Protein Function:KI-67: a protein that may be a marker of proliferating cells, involved in chromatin compaction. Its expression is altered in many tumor types including osteosarcomas, histiocytomas, prostate, breast and esophageal cancers. Mutated in colon, cervical and lung cancers.
UniProt Protein Details:

Protein type:Nucleolus; Cell cycle regulation

Chromosomal Location of Human Ortholog: 10q26.2

Cellular Component: chromosome, pericentric region; condensed chromosome; cytoplasm; membrane; nucleolus; nucleus

Molecular Function:ATP binding; protein binding; protein C-terminus binding

Biological Process: cell proliferation; DNA metabolic process; hyaluronan metabolic process; meiosis; organ regeneration; response to organic cyclic substance

NCBI Summary:This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]
UniProt Code:P46013
NCBI GenInfo Identifier:118572663
NCBI Gene ID:4288
NCBI Accession:P46013.2
UniProt Secondary Accession:P46013,Q5VWH2,
UniProt Related Accession:P46013
Molecular Weight:319,444 Da
NCBI Full Name:Antigen KI-67
NCBI Synonym Full Names:marker of proliferation Ki-67
NCBI Official Symbol:MKI67  
NCBI Official Synonym Symbols:KIA; MIB-; MIB-1; PPP1R105  
NCBI Protein Information:antigen KI-67
UniProt Protein Name:Antigen KI-67
UniProt Gene Name:MKI67  
UniProt Entry Name:KI67_HUMAN
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