Epigenetics & Nuclear Signaling Antibodies 5
Anti-MiTF Antibody (CAB11649)
- SKU:
- CAB11649
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-MiTF Antibody |
| Antibody SKU: | CAB11649 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human MiTF |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat lung |
| Immunogen: | A synthesized peptide derived from human MiTF |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4286 |
| Uniprot: | O75030 |
| Cellular Location: | |
| Calculated MW: | 52kDa |
| Observed MW: | 59KDa |
 | Western blot - MiTF Rabbit mAb (CAB11649) |
| Synonyms: | CMM8, COMMAD, MI, WS2, WS2A, bHLHe32 |
| Background: | This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | MITF: a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. Plays a critical role in the differentiation of various cell types including neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. Two isoforms are known: the M-isoform is expressed exclusively in melanocytes, while the A-isoform has a much broader range of expression. Mutations in MITF can lead to Waardenburg syndrome. Ten alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 3p14.2-p14.1 Cellular Component: protein complex; nucleus Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; protein dimerization activity; protein binding; chromatin binding Biological Process: transcription from RNA polymerase II promoter; regulation of osteoclast differentiation; camera-type eye development; cell fate commitment; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; melanocyte differentiation; protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; osteoclast differentiation; bone remodeling; regulation of cell proliferation Disease: Waardenburg Syndrome, Type 2a; Albinism, Ocular, With Sensorineural Deafness; Melanoma, Cutaneous Malignant, Susceptibility To, 8; Tietz Syndrome |
| NCBI Summary: | This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75030 |
| NCBI GenInfo Identifier: | 13124344 |
| NCBI Gene ID: | 4286 |
| NCBI Accession: | O75030.2 |
| UniProt Secondary Accession: | O75030,Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8, B4DJL2 D3K197, E9PFN0, |
| UniProt Related Accession: | O75030 |
| Molecular Weight: | 526 |
| NCBI Full Name: | Microphthalmia-associated transcription factor |
| NCBI Synonym Full Names: | microphthalmia-associated transcription factor |
| NCBI Official Symbol: | MITF |
| NCBI Official Synonym Symbols: | MI; WS2; CMM8; WS2A; bHLHe32 |
| NCBI Protein Information: | microphthalmia-associated transcription factor; class E basic helix-loop-helix protein 32 |
| UniProt Protein Name: | Microphthalmia-associated transcription factor |
| UniProt Synonym Protein Names: | Class E basic helix-loop-helix protein 32; bHLHe32 |
| Protein Family: | Microphthalmia-associated transcription factor |
| UniProt Gene Name: | MITF |
| UniProt Entry Name: | MITF_HUMAN |
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