Name: Anti-MINPP1 Antibody (CAB10273)
Brand: Cell Biology Antibodies 1
SKU: CAB10273
Availability: OutOfStock

Antibody Name:	Anti-MINPP1 Antibody
Antibody SKU:	CAB10273
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 298-487 of human MINPP1 (NP_004888.2).

Application:	WB
Recommended Dilution:	WB 1:1000 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	293T, U-87MG, SW620, HT-1080, Mouse kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 298-487 of human MINPP1 (NP_004888.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	KSPW CDVF DIDD AKVL EYLN DLKQ YWKR GYGY TINS RSSC TLFQ DIFQ HLDK AVEQ KQRS QPIS SPVI LQFG HAET LLPL LSLM GYFK DKEP LTAY NYKK QMHR KFRS GLIV PYAS NLIF VLYH CENA KTPK EQFR VQML LNEK VLPL AYSQ ETVS FYED LKNH YKDI LQSC QTSE ECEL ARAN STSD EL
Gene ID:	9562
Uniprot:	Q9UNW1
Cellular Location:	Endoplasmic reticulum lumen
Calculated MW:	31kDa/33kDa/34kDa/55kDa
Observed MW:	50kDa

Synonyms:

MINPP1, HIPER1, MINPP2, MIPP

Background:

This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2, 3 bisphosphoglycerate (2, 3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2, 3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.

UniProt Protein Function:	MINPP1: Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification). Defects in MINPP1 may be involved in follicular thyroid tumors development. Belongs to the histidine acid phosphatase family. MINPP1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:EC 3.1.3.80; Hydrolase; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; EC 3.1.3.62; Carbohydrate Metabolism - inositol phosphate Chromosomal Location of Human Ortholog: 10q23 Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen Molecular Function:acid phosphatase activity; phosphohistidine phosphatase activity Biological Process: bone mineralization; dephosphorylation; inositol phosphate metabolic process; ossification; polyphosphate metabolic process Disease: Thyroid Carcinoma, Follicular
NCBI Summary:	This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]
UniProt Code:	Q9UNW1
NCBI GenInfo Identifier:	68565617
NCBI Gene ID:	9562
NCBI Accession:	Q9UNW1.1
UniProt Secondary Accession:	Q9UNW1,O95172, O95286, Q59EJ2, Q9UGA3, F5H683,
UniProt Related Accession:	Q9UNW1
Molecular Weight:	33,100 Da
NCBI Full Name:	Multiple inositol polyphosphate phosphatase 1
NCBI Synonym Full Names:	multiple inositol-polyphosphate phosphatase 1
NCBI Official Symbol:	MINPP1
NCBI Official Synonym Symbols:	MIPP; HIPER1; MINPP2
NCBI Protein Information:	multiple inositol polyphosphate phosphatase 1
UniProt Protein Name:	Multiple inositol polyphosphate phosphatase 1
UniProt Synonym Protein Names:	2,3-bisphosphoglycerate 3-phosphatase (EC:3.1.3.80); 2,3-BPG phosphatase; Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; Ins(1,3,4,5)P(4) 3-phosphatase
Protein Family:	Multiple inositol polyphosphate phosphatase
UniProt Gene Name:	MINPP1
UniProt Entry Name:	MINP1_HUMAN

Western blot analysis of extracts of various cell lines, using MINPP1 antibody (CAB10273) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

Antibodies

MINPP1 Antibody (PACO01066)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)