Anti-Mineralocorticoid receptor (NR3C2) Antibody (CAB21058)
(No reviews yet)
Write a Review
- SKU:
- CAB21058
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
| Antibody Name: | Anti-Mineralocorticoid receptor (NR3C2) Antibody (CAB21058) |
| Antibody SKU: | CAB21058 |
| Antibody Size: | 50µL, 100µL |
| Application: | Western blotting |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-600 of human Mineralocorticoid receptor (NR3C2) (NP_000892.2). |
| Application: | Western blotting |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | PC-3, THP-1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-600 of human Mineralocorticoid receptor (NR3C2) (NP_000892.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FPFM DGSY FSFM DDKD YYSL SGIL GPPV PGFD GNCE GSGF PVGI KQEP DDGS YYPE ASIP SSAI VGVN SGGQ SFHY RIGA QGTI SLSR SARD QSFQ HLSS FPPV NTLV ESWK SHGD LSSR RSDG YPVL EYIP ENVS SSTL RSVS TGSS RPS |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum membrane, Nucleus, Peripheral membrane protein |
| Calculated MW: | 75kDa/94kDa/107kDa |
| Observed MW: | 100KDa |
| Synonyms: | NR3C2, MCR, MLR, MR, NR3C2VIT |
| Background: | This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. |
 | Western blot analysis of extracts of various cell lines, using Mineralocorticoid receptor (NR3C2) antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s. |
Related Products
Mouse Nr3c2(Mineralocorticoid receptor) ELISA Kit
OverviewProduct Name:Mouse Nr3c2(Mineralocorticoid receptor) ELISA KitProduct Code:AEFI00538Size:96TAlias:Mineralocorticoid receptor, MR
