Cell Biology Antibodies 10

Anti-MINA Antibody (CAB6655)

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SKU:
CAB6655
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MINA Antibody
Antibody SKU:CAB6655
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human MINA (NP_694822.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:SKOV3, BT-474, NCI-H460, HeLa, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human MINA (NP_694822.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPKK AKPT GSGK EEGP APCK QMKL EAAG GPSA LNFD SPSS LFES LISP IKTE TFFK EFWE QKPL LIQR DDPA LATY YGSL FKLT DLKS LCSR GMYY GRDV NVCR CVNG KKKV LNKD GKAH FLQL RKDF DQKR ATIQ FHQP QRFK DELW RIQE KLEC YFGS LVGS NVYI TPAG SQGL PPHY DDVE VFIL QLEG EKHW RLYH PTVP LARE YSVE AEER IGRP VHEF MLKP GDLL YFPR GTIH QADT PAGL AHST HVTI STYQ NNSW GDFL LDTI SGLV FDTA KEDV ELRT GIPR QLLL QVES
Gene ID:84864
Uniprot:Q8IUF8
Cellular Location:Nucleus, nucleolus
Calculated MW:23kDa/31kDa/52kDa
Observed MW:53kDa
Synonyms:RIOX2, JMJD10, MDIG, MINA, MINA53, NO52, ROX
Background:
UniProt Protein Function:MINA: Involved in cellular proliferation. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. Belongs to the MINA53/NO66 family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nucleolus

Chromosomal Location of Human Ortholog: 3q11.2

Cellular Component: transcription factor complex; cytoplasm; nucleolus; cytosol; nucleus

Molecular Function:dioxygenase activity; metal ion binding

Biological Process: transcription, DNA-dependent; ribosome biogenesis and assembly; negative regulation of transcription from RNA polymerase II promoter

NCBI Summary:MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
UniProt Code:Q8IUF8
NCBI GenInfo Identifier:74750624
NCBI Gene ID:84864
NCBI Accession:Q8IUF8.1
UniProt Related Accession:Q8IUF8
Molecular Weight:
NCBI Full Name:Ribosomal oxygenase 2
NCBI Synonym Full Names:ribosomal oxygenase 2
NCBI Official Symbol:RIOX2  
NCBI Official Synonym Symbols:ROX; MDIG; MINA; NO52; JMJD10; MINA53  
NCBI Protein Information:ribosomal oxygenase 2
UniProt Protein Name:Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
UniProt Synonym Protein Names:60S ribosomal protein L27a histidine hydroxylase; Histone lysine demethylase MINA; MYC-induced nuclear antigen; Mineral dust-induced gene protein; Nucleolar protein 52; Ribosomal oxygenase MINA; ROX
Protein Family:Bifunctional lysine-specific demethylase and histidyl-hydroxylase
UniProt Gene Name:MINA  
UniProt Entry Name:MINA_HUMAN
Anti-MINA Antibody (CAB6655)Western blot analysis of extracts of various cell lines, using MINA antibody (CAB6655) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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