Cell Biology Antibodies 5

Anti-MIIP Antibody (CAB14417)

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SKU:
CAB14417
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MIIP Antibody
Antibody SKU:CAB14417
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 279-388 of human MIIP (NP_068752.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 279-388 of human MIIP (NP_068752.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AHVR VSIP LSIL EPPH RYHI HRRK SFDA SDTL ALPR HCLL GWDI FPPK SEKS SAPR NLDL WSSV SAEA QHQK LSGT SSPF HPAS PMQM LPPT PTWS VPQV PRPH VPRQ KP
Gene ID:60672
Uniprot:Q5JXC2
Cellular Location:
Calculated MW:39kDa/42kDa
Observed MW:43kDa
Synonyms:MIIP, IIP45
Background:This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers.
UniProt Protein Function:MIIP: Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 1p36.22

Molecular Function:protein binding

NCBI Summary:This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]
UniProt Code:Q5JXC2
NCBI GenInfo Identifier:296439302
NCBI Gene ID:60672
NCBI Accession:Q5JXC2.3
UniProt Secondary Accession:Q5JXC2,Q96HU6, Q9H839, Q9HA00, C0KL22,
UniProt Related Accession:Q5JXC2
Molecular Weight:39,292 Da
NCBI Full Name:Migration and invasion-inhibitory protein
NCBI Synonym Full Names:migration and invasion inhibitory protein
NCBI Official Symbol:MIIP  
NCBI Official Synonym Symbols:IIP45  
NCBI Protein Information:migration and invasion-inhibitory protein
UniProt Protein Name:Migration and invasion-inhibitory protein
UniProt Synonym Protein Names:IGFBP2-binding protein; Invasion-inhibitory protein 45; IIp45
Protein Family:Migration and invasion-inhibitory protein
UniProt Gene Name:MIIP  
UniProt Entry Name:MIIP_HUMAN
Anti-MIIP Antibody (CAB14417)Western blot analysis of extracts of HeLa cells, using MIIP antibody (CAB14417) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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