Cell Biology Antibodies 13
Anti-MICU1 Antibody (CAB17613)
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- SKU:
- CAB17613
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MICU1 Antibody |
| Antibody SKU: | CAB17613 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-200 of human MICU1 (NP_001182447.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-200 of human MICU1 (NP_001182447.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LLWK RAHA ESPP CVDN LKSD IGDK GKNK DEGD VCNH EKKT ADLA PHPE EKKK KRSG FRDR KVME YENR IRAY STPD KIFR YFAT LKVI SEPG EAEV FMTP EDFV RSIT PNEK QPEH LGLD QYII KRFD GKKI SQER EKFA DEGS IFYT LGE |
| Gene ID: | 10367 |
| Uniprot: | Q9BPX6 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | CALC, CBARA1, EFHA3, MPXPS, MICU1 |
| Background: | This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013] |
| UniProt Protein Function: | MICU1: Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Belongs to the MICU1 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Mitochondrial; Calcium-binding Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: intracellular; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion Molecular Function:calcium ion binding; identical protein binding; protein binding; protein heterodimerization activity Biological Process: defense response; elevation of mitochondrial calcium ion concentration; mitochondrial calcium ion homeostasis; mitochondrial calcium ion transport; protein homooligomerization Disease: Myopathy With Extrapyramidal Signs |
| NCBI Summary: | This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013] |
| UniProt Code: | Q9BPX6 |
| NCBI GenInfo Identifier: | 74761192 |
| NCBI Gene ID: | 10367 |
| NCBI Accession: | Q9BPX6.1 |
| UniProt Secondary Accession: | Q9BPX6,O75785, Q9H9N6, Q9UFX0, A8MV96, B3KN20, B4DJH9 B4DPI1, B5MBY3, D3YTJ3, |
| UniProt Related Accession: | Q9BPX6 |
| Molecular Weight: | 31,931 Da |
| NCBI Full Name: | Calcium uptake protein 1, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial calcium uptake 1 |
| NCBI Official Symbol: | MICU1 |
| NCBI Official Synonym Symbols: | CALC; EFHA3; MPXPS; CBARA1 |
| NCBI Protein Information: | calcium uptake protein 1, mitochondrial |
| UniProt Protein Name: | Calcium uptake protein 1, mitochondrial |
| UniProt Synonym Protein Names: | Atopy-related autoantigen CALC; ara CALC; Calcium-binding atopy-related autoantigen 1; Allergen: Hom s 4 |
| Protein Family: | Calcium uptake protein |
| UniProt Gene Name: | MICU1 |
| UniProt Entry Name: | MICU1_HUMAN |
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