Cell Biology Antibodies 15

Anti-MIB2 Antibody (CAB17829)

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SKU:
CAB17829
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MIB2 Antibody
Antibody SKU:CAB17829
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-580 of human MIB2 (NP_001164158.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, BxPC-3, U-87MG, Mouse lung, Mouse testis, Mouse brain, Rat brain, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-580 of human MIB2 (NP_001164158.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ASVT WADG TTNV YRVG HKGK VDLK CVGE AAGG FYYK DHLP RLGK PAEL QRRV SADS QPFQ HGDK VKCL LDTD VLRE MQEG HGGW NPRM AEFI GQTG TVHR ITDR GDVR VQFN HETR WTFH PGAL TKHH SFWV GDVV RVIG DLDT VKRL QAGH GEWT DDMA PALG RVGK VVKV FGDG NLRV AVAG QRWT FSPS CLVA YRPE EDAN LDVA ERAR ENKS SLSV ALDK LRAQ KSDP EHPG RLVV EVAL GNAA RALD LLRR RPEQ VDTK NQGR TALQ VAAY LGQV E
Gene ID:142678
Uniprot:Q96AX9
Cellular Location:
Calculated MW:
Observed MW:110kDa
Anti-MIB2 Antibody (CAB17829)Western blot - MIB2 Polyclonal Antibody (CAB17829)
Synonyms:ZZANK1, ZZZ5, MIB2
Background:The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017]
UniProt Protein Function:MIB2: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. 9 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin ligase; Ligase; EC 6.3.2.-; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: cytoplasm; cytosol

Molecular Function:protein binding; signal transducer activity; ubiquitin-protein ligase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; protein polyubiquitination

UniProt Code:Q96AX9
NCBI GenInfo Identifier:209572707
NCBI Gene ID:142678
NCBI Accession:Q96AX9.3
UniProt Secondary Accession:Q96AX9,Q7Z437, A2AGM5, A2AGM6, B3KV93, B3KVF4, B3KXY1 B4DZ57, E9PGU1, E9PHQ1, F8WA73, J3KNZ7,
UniProt Related Accession:Q96AX9
Molecular Weight:115,861 Da
NCBI Full Name:E3 ubiquitin-protein ligase MIB2
NCBI Synonym Full Names:mindbomb E3 ubiquitin protein ligase 2
NCBI Official Symbol:MIB2  
NCBI Official Synonym Symbols:ZZZ5; ZZANK1  
NCBI Protein Information:E3 ubiquitin-protein ligase MIB2
UniProt Protein Name:E3 ubiquitin-protein ligase MIB2
UniProt Synonym Protein Names:Mind bomb homolog 2; Novel zinc finger protein; Novelzin; Putative NF-kappa-B-activating protein 002N; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:MIB2  
UniProt Entry Name:MIB2_HUMAN
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