Name: Anti-MHC class I Antibody (CAB8754)
Brand: Cell Biology Antibodies 15
SKU: CAB8754
Availability: OutOfStock

Antibody Name:	Anti-MHC class I Antibody
Antibody SKU:	CAB8754
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	A synthesized peptide derived from human MHC class I

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:	Human
Positive Samples:	HeLa, HepG2, MCF7, Jurkat

Immunogen:	A synthesized peptide derived from human MHC class I
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	3105/3106
Uniprot:	P30443/P01889/P01891/P01892/P13746/P16188/P30450
Cellular Location:
Calculated MW:	41kDa
Observed MW:	44KDa

Synonyms:

HLAA

Background:

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]

UniProt Protein Function:	Involved in the presentation of foreign antigens to the immune system.
NCBI Summary:	HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
UniProt Code:	P30443
NCBI GenInfo Identifier:	231347
NCBI Gene ID:	3105
NCBI Accession:	P30443.1
UniProt Secondary Accession:	P30443,O77964, O78171, Q9MYA3, Q9TP25, Q9TQP5,
UniProt Related Accession:	P01891,P01892,P04439,P05534,P10314,P10316,P13746,P16188,P16189,P16190
Molecular Weight:	40,846 Da
NCBI Full Name:	HLA class I histocompatibility antigen, A-1 alpha chain
NCBI Synonym Full Names:	major histocompatibility complex, class I, A
NCBI Official Symbol:	HLA-A
NCBI Official Synonym Symbols:	HLAA
NCBI Protein Information:	HLA class I histocompatibility antigen, A-1 alpha chain; LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-1 alpha chain
UniProt Protein Name:	HLA class I histocompatibility antigen, A-1 alpha chain
UniProt Synonym Protein Names:	MHC class I antigen A*1
Protein Family:	HLA class I histocompatibility antigen
UniProt Gene Name:	HLA-A