Cell Biology Antibodies 9
Anti-MGP Antibody (CAB5439)
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- SKU:
- CAB5439
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MGP Antibody |
| Antibody SKU: | CAB5439 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-103 of human MGP (NP_000891.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, U-87MG, A375, BT-474, 3T3L1, Mouse kidney, Mouse lung, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-103 of human MGP (NP_000891.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YESH ESME SYEL NPFI NRRN ANTF ISPQ QRWR AKVQ ERIR ERSK PVHE LNRE ACDD YRLC ERYA MVYG YNAA YNRY FRKR RGTK |
| Gene ID: | 4256 |
| Uniprot: | P08493 |
| Cellular Location: | Secreted |
| Calculated MW: | 12kDa/15kDa |
| Observed MW: | 12kDa |
| Synonyms: | MGP, GIG36, MGLAP, NTI |
| Background: | The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | MGP: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. Defects in MGP are the cause of Keutel syndrome (KS). KS is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. Belongs to the osteocalcin/matrix Gla protein family. |
| UniProt Protein Details: | Protein type:Secreted; Extracellular matrix; Secreted, signal peptide Chromosomal Location of Human Ortholog: 12p12.3 Cellular Component: extracellular matrix; proteinaceous extracellular matrix Molecular Function:protein binding; structural constituent of bone; extracellular matrix structural constituent; calcium ion binding Biological Process: ossification; cell differentiation; regulation of bone mineralization; cartilage condensation Disease: Keutel Syndrome |
| NCBI Summary: | The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P08493 |
| NCBI GenInfo Identifier: | 118572668 |
| NCBI Gene ID: | 4256 |
| NCBI Accession: | P08493.2 |
| UniProt Secondary Accession: | P08493,Q2TU41, Q567P9, Q6ICN5, A0M8W5, B2R519, J3KMX7 |
| UniProt Related Accession: | P08493 |
| Molecular Weight: | 103 |
| NCBI Full Name: | Matrix Gla protein |
| NCBI Synonym Full Names: | matrix Gla protein |
| NCBI Official Symbol: | MGP |
| NCBI Official Synonym Symbols: | NTI; GIG36; MGLAP |
| NCBI Protein Information: | matrix Gla protein; cell growth-inhibiting gene 36 protein |
| UniProt Protein Name: | Matrix Gla protein |
| UniProt Synonym Protein Names: | Cell growth-inhibiting gene 36 protein |
| Protein Family: | Matrix Gla protein |
| UniProt Gene Name: | MGP |
| UniProt Entry Name: | MGP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MGP antibody (CAB5439) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s. |
 | Immunohistochemistry of paraffin-embedded rat brain using MGP antibody (CAB5439) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using MGP antibody (CAB5439) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse stomach using MGP antibody (CAB5439) at dilution of 1:100 (40x lens). |
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