Anti-mGluR2 Antibody (CAB3673)

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SKU:
CAB3673
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
GLUR2
Synonyms:
GPRC1B
Synonyms:
MGLUR2
Synonyms:
mGlu2
Research Area:
Cell Biology

Description

Product Name:mGluR2 Rabbit mAb
Product Code:CAB3673
Size:20uL, 50uL, 100uL
Synonyms:GLUR2, GPRC1B, MGLUR2, mGlu2
Applications:WB, IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human mGluR2
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human mGluR2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2912
Uniprot:Q14416
Cellular Location:Cell junction, Cell membrane, Cell projection, Multi-pass membrane protein, dendrite, synapse
Calculated MW:95, 200kDa
Observed MW:80kDa???
UniProt Protein Function:mGluR2: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Belongs to the G-protein coupled receptor 3 family.
UniProt Protein Details:

Protein type:GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:calcium channel regulator activity; G-protein coupled receptor activity; glutamate receptor activity; protein binding

Biological Process: metabotropic glutamate receptor signaling pathway; negative regulation of adenylate cyclase activity; regulation of synaptic transmission, glutamatergic; synaptic transmission

NCBI Summary:L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
UniProt Code:Q14416
NCBI GenInfo Identifier:76803802
NCBI Gene ID:2912
NCBI Accession:Q14416.2
UniProt Secondary Accession:Q14416,Q14CU5, Q52MC6, Q9H3N6, B0M0K7,
UniProt Related Accession:Q14416
Molecular Weight:96kDa
NCBI Full Name:Metabotropic glutamate receptor 2
NCBI Synonym Full Names:glutamate metabotropic receptor 2
NCBI Official Symbol:GRM2  
NCBI Official Synonym Symbols:GLUR2; mGlu2; GPRC1B; MGLUR2  
NCBI Protein Information:metabotropic glutamate receptor 2
UniProt Protein Name:Metabotropic glutamate receptor 2
Protein Family:Metabotropic glutamate receptor
UniProt Gene Name:GRM2  
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