Cell Biology Antibodies 15
Anti-MEX3C Antibody (CAB8393)
- SKU:
- CAB8393
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Description
Antibody Name: | Anti-MEX3C Antibody |
Antibody SKU: | CAB8393 |
Antibody Size: | 20µL, 50µL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 484-659 of human MEX3C (NP_057710.3). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: | SH-SY5Y |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 484-659 of human MEX3C (NP_057710.3). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | LPSV GSED LAVD SPAF DSLP TSAQ TIWT PFEP VNPL SGFG SDPS GNMK TQRR GSQP STPR LSPT FPES IEHP LARR VRSD PPST GNHV GLPI YIPA FSNG TNSY SSSN GGST SSSP PESR RKHD CVIC FENE VIAA LVPC GHNL FCME CANK ICEK RTPS CPVC QTAV TQAI QIHS |
Gene ID: | 51320 |
Uniprot: | Q5U5Q3 |
Cellular Location: | Cytoplasm, Nucleus |
Calculated MW: | 69kDa |
Observed MW: | 73kDa |
Synonyms: | MEX3C, BM-013, MEX-3C, RKHD2, RNF194, Mex3C |
Background: | This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. |
UniProt Protein Function: | RKHD2: E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. Genetic variations in MEX3C may be associated with susceptibility to essential hypertension. |
UniProt Protein Details: | Protein type:RNA-binding; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 18q21.2 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; zinc ion binding; ligase activity Biological Process: regulation of fat cell differentiation; metabolic process Disease: Hypertension, Essential, Susceptibility To, 8 |
NCBI Summary: | This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009] |
UniProt Code: | Q5U5Q3 |
NCBI GenInfo Identifier: | 148229134 |
NCBI Gene ID: | 51320 |
NCBI Accession: | NP_057710 |
UniProt Related Accession: | Q5U5Q3 |
Molecular Weight: | |
NCBI Full Name: | RNA-binding E3 ubiquitin-protein ligase MEX3C |
NCBI Synonym Full Names: | mex-3 RNA binding family member C |
NCBI Official Symbol: | MEX3C |
NCBI Official Synonym Symbols: | RKHD2; BM-013; MEX-3C; RNF194 |
NCBI Protein Information: | RNA-binding E3 ubiquitin-protein ligase MEX3C |
UniProt Protein Name: | RNA-binding E3 ubiquitin-protein ligase MEX3C |
UniProt Synonym Protein Names: | RING finger and KH domain-containing protein 2; RING finger protein 194 |
Protein Family: | RNA-binding E3 ubiquitin-protein ligase |
UniProt Gene Name: | MEX3C |
UniProt Entry Name: | MEX3C_HUMAN |
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