Epigenetics & Nuclear Signaling Antibodies 1

Anti-METTL2B Antibody (CAB12082)

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SKU:
CAB12082
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-METTL2B Antibody
Antibody SKU:CAB12082
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 100-250 of human METTL2B (NP_060866.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, Jurkat, U-87MG, HT-29, A-431
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 100-250 of human METTL2B (NP_060866.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FPEL APSQ NQNH LKDW FLEN KSEV CECR NNED GPGL IMEE QHKC SSKS LEHK TQTP PVEE NVTQ KISD LEIC ADEF PGSS ATYR ILEV GCGV GNTV FPIL QTNN DPGL FVYC CDFS STAI ELVQ TNSE YDPS RCFA FVHD LCDE EKSY PVP
Gene ID:55798
Uniprot:Q6P1Q9
Cellular Location:
Calculated MW:36kDa/43kDa
Observed MW:40kDa
Synonyms:METTL2B, METL, METTL2, METTL2A, PSENIP1
Background:This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
UniProt Protein Function:METTL2B: Probable methyltransferase. Belongs to the methyltransferase superfamily. METL family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.1.1.-; Amino Acid Metabolism - histidine; Methyltransferase; Other Amino Acids Metabolism - selenoamino acid; Lipid Metabolism - androgen and estrogen; Amino Acid Metabolism - tyrosine

Chromosomal Location of Human Ortholog: 7q32.1

Molecular Function:tRNA (cytosine)-methyltransferase activity

Biological Process: tRNA methylation

NCBI Summary:This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q6P1Q9
NCBI GenInfo Identifier:317373413
NCBI Gene ID:55798
NCBI Accession:Q6P1Q9.3
UniProt Secondary Accession:Q6P1Q9,Q0IJ54, Q3B7J1, B4DZ68,
UniProt Related Accession:Q6P1Q9
Molecular Weight:36,057 Da
NCBI Full Name:Methyltransferase-like protein 2B
NCBI Synonym Full Names:methyltransferase like 2B
NCBI Official Symbol:METTL2B  
NCBI Official Synonym Symbols:METL; METTL2; METTL2A; PSENIP1  
NCBI Protein Information:methyltransferase-like protein 2B
UniProt Protein Name:Methyltransferase-like protein 2B
Protein Family:Methyltransferase-like protein
UniProt Gene Name:METTL2B  
UniProt Entry Name:MET2B_HUMAN
Anti-METTL2B Antibody (CAB12082)Western blot analysis of extracts of various cell lines, using METTL2B antibody (CAB12082) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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