Epigenetics & Nuclear Signaling Antibodies 3
Anti-METTL1 Antibody (CAB16651)
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- SKU:
- CAB16651
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-METTL1 Antibody |
| Antibody SKU: | CAB16651 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human METTL1 (NP_005362.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, 293T, LO2, HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-276 of human METTL1 (NP_005362.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAE TRNV AGAE APPP QKRY YRQR AHSN PMAD HTLR YPVK PEEM DWSE LYPE FFAP LTQN QSHD DPKD KKEK RAQA QVEF ADIG CGYG GLLV ELSP LFPD TLIL GLEI RVKV SDYV QDRI RALR AAPA GGFQ NIAC LRSN AMKH LPNF FYKG QLTK MFFL FPDP HFKR TKHK WRII SPTL LAEY AYVL RVGG LVYT ITDV LELH DWMC THFE EHPL FERV PLED LSED PVVG HLGT STEE GKKV LRNG GKNF PAIF RRIQ DPVL QAVT SQTS LPGH |
| Gene ID: | 4234 |
| Uniprot: | Q9UBP6 |
| Cellular Location: | Nucleus |
| Calculated MW: | 17kDa/31kDa |
| Observed MW: | 37kDa |
| Synonyms: | METTL1, C12orf1, TRM8, TRMT8, YDL201w |
| Background: | This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. |
| UniProt Protein Function: | Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. |
| NCBI Summary: | This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBP6 |
| NCBI GenInfo Identifier: | 32171926 |
| NCBI Gene ID: | 4234 |
| NCBI Accession: | Q9UBP6.1 |
| UniProt Secondary Accession: | Q9UBP6,Q14105, Q53FS9, B2RBX1, H7BXF2, |
| UniProt Related Accession: | Q9UBP6 |
| Molecular Weight: | 17,423 Da |
| NCBI Full Name: | tRNA (guanine-N(7)-)-methyltransferase |
| NCBI Synonym Full Names: | methyltransferase like 1 |
| NCBI Official Symbol: | METTL1 |
| NCBI Official Synonym Symbols: | TRM8; TRMT8; C12orf1; YDL201w |
| NCBI Protein Information: | tRNA (guanine-N(7)-)-methyltransferase |
| UniProt Protein Name: | tRNA (guanine-N(7)-)-methyltransferase |
| UniProt Synonym Protein Names: | Methyltransferase-like protein 1 |
| UniProt Gene Name: | METTL1 |
| UniProt Entry Name: | TRMB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using METTL1 antibody (CAB16651) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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