Anti-Methyl-U2AF1-H37 Antibody (CAB18824)

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SKU:
CAB18824
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
U2AF1
Synonyms:
FP793
Synonyms:
RN
Synonyms:
RNU2AF1
Synonyms:
U2AF35
Synonyms:
U2AFBP
Synonyms:
splicing factor U2AF 35 kDa subunit
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:Methyl-U2AF1-H37 Rabbit pAb
Product Code:CAB18824
Size:20uL, 50uL, 100uL
Synonyms:U2AF1, FP793, RN, RNU2AF1, U2AF35, U2AFBP, splicing factor U2AF 35 kDa subunit
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human Methyl-U2AF1-H37, 3-methyl (tau-methyl).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A synthetic peptide of human Methyl-U2AF1-H37, 3-methyl (tau-methyl).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7307
Uniprot:Q01081
Cellular Location:Nucleus, Nucleus speckle
Calculated MW:8kDa/19kDa/27kDa
Observed MW:Refer to figures
UniProt Protein Function:U2AF1: Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. Belongs to the splicing factor SR family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Spliceosome; RNA splicing; RNA-binding; RNA processing

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleoplasm; spliceosome; Cajal body; nuclear speck

Molecular Function:RS domain binding; protein binding; metal ion binding; nucleotide binding

Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; RNA splicing; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription

NCBI Summary:This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q01081
NCBI GenInfo Identifier:267187
NCBI Gene ID:7307
NCBI Accession:Q01081.3
UniProt Secondary Accession:Q01081,Q701P4, Q71RF1,
UniProt Related Accession:Q01081
Molecular Weight:240
NCBI Full Name:Splicing factor U2AF 35 kDa subunit
NCBI Synonym Full Names:U2 small nuclear RNA auxiliary factor 1
NCBI Official Symbol:U2AF1  
NCBI Official Synonym Symbols:RN; FP793; U2AF35; U2AFBP; RNU2AF1  
NCBI Protein Information:splicing factor U2AF 35 kDa subunit; splicing factor U2AF 35kDa subunit; U2 small nuclear RNA auxillary factor 1; U2 snRNP auxiliary factor small subunit; U2(RNU2) small nuclear RNA auxiliary factor binding protein; U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit
UniProt Protein Name:Splicing factor U2AF 35 kDa subunit
UniProt Synonym Protein Names:U2 auxiliary factor 35 kDa subunit; U2 small nuclear RNA auxiliary factor 1; U2 snRNP auxiliary factor small subunit
Protein Family:Splicing factor
UniProt Gene Name:U2AF1  
UniProt Entry Name:U2AF1_HUMAN
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