Anti-Methyl-HP1 gamma/CBX3-H175 Antibody (CAB18812)

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SKU:
CAB18812
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CBX3
Synonyms:
HECH
Synonyms:
HP1-GAMMA
Synonyms:
HP1Hs-gamma
Synonyms:
chromobox 3
Research Area:
Cell Biology

Description

Product Name:Methyl-HP1 gamma/CBX3-H175 Rabbit pAb
Product Code:CAB18812
Size:20uL, 50uL, 100uL
Synonyms:CBX3, HECH, HP1-GAMMA, HP1Hs-gamma, chromobox 3
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human Methyl-HP1 gamma/CBX3-H175, 3-methyl (tau-methyl).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A synthetic peptide of human Methyl-HP1 gamma/CBX3-H175, 3-methyl (tau-methyl).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:11335
Uniprot:Q13185
Cellular Location:Nucleus
Calculated MW:20kDa
Observed MW:Refer to figures
UniProt Protein Function:CBX3: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2 and SP100. Interacts with TIF1A. Interacts with MIS12 and DSN1. Can interact directly with CBX5 via the chromoshadow domain. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: chromatin; chromocenter; chromosome, pericentric region; nuclear chromosome, telomeric region; nuclear envelope; nuclear heterochromatin; nuclear inner membrane; nucleus; spindle

Molecular Function:enzyme binding; identical protein binding; protein binding; protein domain specific binding

Biological Process: chromatin remodeling; negative regulation of transcription, DNA-dependent; rhythmic process; transcription, DNA-dependent

NCBI Summary:At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
UniProt Code:Q13185
NCBI GenInfo Identifier:116241284
NCBI Gene ID:11335
NCBI Accession:Q13185.4
UniProt Secondary Accession:Q13185,Q96CD7, Q99409, Q9BVS3, Q9P0Z6,
UniProt Related Accession:Q13185
Molecular Weight:20,811 Da
NCBI Full Name:Chromobox protein homolog 3
NCBI Synonym Full Names:chromobox 3
NCBI Official Symbol:CBX3  
NCBI Official Synonym Symbols:HECH; HP1-GAMMA; HP1Hs-gamma  
NCBI Protein Information:chromobox protein homolog 3
UniProt Protein Name:Chromobox protein homolog 3
UniProt Synonym Protein Names:HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 protein
Protein Family:Chromobox protein
UniProt Gene Name:CBX3  
UniProt Entry Name:CBX3_HUMAN
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