Cell Biology Antibodies 11
Anti-Metaxin-2 Antibody (CAB7958)
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- SKU:
- CAB7958
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | MTX2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB7958 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-263 of human MTX2 (NP_006545.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, NCI-H460, Mouse liver, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-263 of human MTX2 (NP_006545.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSLV AEAF VSQI AAAE PWPE NATL YQQL KGEQ ILLS DNAA SLAV QAFL QMCN LPIK VVCR ANAE YMSP SGKV PFIH VGNQ VVSE LGPI VQFV KAKG HSLS DGLE EVQK AEMK AYME LVNN MLLT AELY LQWC DEAT VGEI THAR YGSP YPWP LNHI LAYQ KQWE VKRK MKAI GWGK KTLD QVLE DVDQ CCQA LSQR LGTQ PYFF NKQP TELD ALVF GHLY TILT TQLT NDEL SEKV KNYS NLLA FCRR IEQH YFED RGKG RLS |
| Gene ID: | 10651 |
| Uniprot: | O75431 |
| Cellular Location: | Mitochondrion, Mitochondrion outer membrane |
| Calculated MW: | 28kDa/29kDa |
| Observed MW: | 29kDa |
| Synonyms: | MTX2, metaxin-2 |
| Background: | The protein encoded by this gene is highly similar to the metaxin 2 protein from mouse, which has been shown to interact with the mitochondrial membrane protein metaxin 1. Because of this similarity, it is thought that the encoded protein is peripherally associated with the cytosolic face of the outer mitochondrial membrane, and that it is involved in the import of proteins into the mitochondrion. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. |
| UniProt Protein Function: | MTX2: Involved in transport of proteins into the mitochondrion. Belongs to the metaxin family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: mitochondrial outer membrane Biological Process: cellular protein metabolic process; protein targeting to mitochondrion; mitochondrial transport |
| NCBI Summary: | The protein encoded by this gene is highly similar to the metaxin 2 protein from mouse, which has been shown to interact with the mitochondrial membrane protein metaxin 1. Because of this similarity, it is thought that the encoded protein is peripherally associated with the cytosolic face of the outer mitochondrial membrane, and that it is involved in the import of proteins into the mitochondrion. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jun 2009] |
| UniProt Code: | O75431 |
| NCBI GenInfo Identifier: | 13124345 |
| NCBI Gene ID: | 10651 |
| NCBI Accession: | O75431.1 |
| UniProt Related Accession: | O75431 |
| Molecular Weight: | |
| NCBI Full Name: | Metaxin-2 |
| NCBI Synonym Full Names: | metaxin 2 |
| NCBI Official Symbol: | MTX2 |
| NCBI Protein Information: | metaxin-2 |
| UniProt Protein Name: | Metaxin-2 |
| UniProt Synonym Protein Names: | Mitochondrial outer membrane import complex protein 2 |
| Protein Family: | Metaxin |
| UniProt Gene Name: | MTX2 |
| UniProt Entry Name: | MTX2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MTX2 antibody (CAB7958) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse heart using MTX2 antibody (CAB7958) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse stomach using MTX2 antibody (CAB7958) at dilution of 1:100 (40x lens). |
 | Confocal immunofluorescence analysis of U2OS cells using MTX2 Polyclonal Antibody (CAB7958) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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