Anti-Mesothelin Antibody (CAB9180)
- SKU:
- CAB9180
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MPF
- Synonyms:
- SMRP
- Research Area:
- Cell Biology
Description
| Product Name: | Mesothelin Rabbit mAb |
| Product Code: | CAB9180 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | MPF, SMRP |
| Applications: | WB, IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Mesothelin |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | HeLa, OVCAR3 |
| Immunogen: | A synthesized peptide derived from human Mesothelin |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10232 |
| Uniprot: | Q13421 |
| Calculated MW: | 69, 40kDa |
| Observed MW: | 48KDa |
| UniProt Protein Function: | MSLN: Membrane-anchored forms may play a role in cellular adhesion. Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. Belongs to the mesothelin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Cell adhesion Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: Golgi apparatus; extracellular space; cell surface; membrane; plasma membrane Molecular Function:protein binding Biological Process: pancreas development; cell adhesion |
| NCBI Summary: | This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] |
| UniProt Code: | Q13421 |
| NCBI GenInfo Identifier: | 116242654 |
| NCBI Gene ID: | 10232 |
| NCBI Accession: | Q13421.2 |
| UniProt Secondary Accession: | Q13421,Q14859, Q4VQD5, Q96GR6, Q96KJ5, Q9BR17, Q9BTR2 Q9UCB2, Q9UK57, D3DU65, |
| UniProt Related Accession: | Q13421 |
| Molecular Weight: | 67,940 Da |
| NCBI Full Name: | Mesothelin |
| NCBI Synonym Full Names: | mesothelin |
| NCBI Official Symbol: | MSLN |
| NCBI Official Synonym Symbols: | MPF; SMRP |
| NCBI Protein Information: | mesothelin; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor |
| UniProt Protein Name: | Mesothelin |
| UniProt Synonym Protein Names: | CAK1 antigen; Pre-pro-megakaryocyte-potentiating factorCleaved into the following 2 chains:Megakaryocyte-potentiating factor; MPF; Mesothelin, cleaved form |
| Protein Family: | Mesothelin |
| UniProt Gene Name: | MSLN |
| UniProt Entry Name: | MSLN_HUMAN |
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