Anti-Mesothelin Antibody (CAB9180)

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SKU:
CAB9180
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MPF
Synonyms:
SMRP
Research Area:
Cell Biology

Description

Product Name:Mesothelin Rabbit mAb
Product Code:CAB9180
Size:20uL, 50uL, 100uL
Synonyms:MPF, SMRP
Applications:WB, IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Mesothelin
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:HeLa, OVCAR3
Immunogen:A synthesized peptide derived from human Mesothelin
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10232
Uniprot:Q13421
Calculated MW:69, 40kDa
Observed MW:48KDa
UniProt Protein Function:MSLN: Membrane-anchored forms may play a role in cellular adhesion. Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. Belongs to the mesothelin family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor; Cell adhesion

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: Golgi apparatus; extracellular space; cell surface; membrane; plasma membrane

Molecular Function:protein binding

Biological Process: pancreas development; cell adhesion

NCBI Summary:This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
UniProt Code:Q13421
NCBI GenInfo Identifier:116242654
NCBI Gene ID:10232
NCBI Accession:Q13421.2
UniProt Secondary Accession:Q13421,Q14859, Q4VQD5, Q96GR6, Q96KJ5, Q9BR17, Q9BTR2 Q9UCB2, Q9UK57, D3DU65,
UniProt Related Accession:Q13421
Molecular Weight:67,940 Da
NCBI Full Name:Mesothelin
NCBI Synonym Full Names:mesothelin
NCBI Official Symbol:MSLN  
NCBI Official Synonym Symbols:MPF; SMRP  
NCBI Protein Information:mesothelin; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor
UniProt Protein Name:Mesothelin
UniProt Synonym Protein Names:CAK1 antigen; Pre-pro-megakaryocyte-potentiating factorCleaved into the following 2 chains:Megakaryocyte-potentiating factor; MPF; Mesothelin, cleaved form
Protein Family:Mesothelin
UniProt Gene Name:MSLN  
UniProt Entry Name:MSLN_HUMAN
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