Metabolism Antibodies 1
Anti-MESDC2 Antibody (CAB13931)
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- SKU:
- CAB13931
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-MESDC2 Antibody |
| Antibody SKU: | CAB13931 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-234 of human MESDC2 (NP_055969.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-431, HepG2, SGC-7901, Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-234 of human MESDC2 (NP_055969.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAS RWAR KAVV LLCA SDLL LLLL LLPP PGSC AAEG SPGT PDES TPPP RKKK KDIR DYND ADMA RLLE QWEK DDDI EEGD LPEH KRPS APVD FSKI DPSK PESI LKMT KKGK TLMM FVTV SGSP TEKE TEEI TSLW QGSL FNAN YDVQ RFIV GSDR AIFM LRDG SYAW EIKD FLVG QDRC ADVT LEGQ VYPG KGGG SKEK NKTK QDKG KKKK EGDL KSRS SKEE NRAG NKRE DL |
| Gene ID: | 23184 |
| Uniprot: | Q14696 |
| Cellular Location: | Endoplasmic reticulum |
| Calculated MW: | 26kDa |
| Observed MW: | 26kDa |
| Synonyms: | MESDC2, BOCA, MESD |
| Background: |
| UniProt Protein Function: | MESDC2: Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Belongs to the MESD family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 15q13 Biological Process: protein folding |
| UniProt Code: | Q14696 |
| NCBI GenInfo Identifier: | 24418861 |
| NCBI Gene ID: | 23184 |
| NCBI Accession: | Q14696.2 |
| UniProt Secondary Accession: | Q14696,Q969U1, B4DW84, D3DW96, |
| UniProt Related Accession: | Q14696 |
| Molecular Weight: | 14,895 Da |
| NCBI Full Name: | LDLR chaperone MESD |
| NCBI Synonym Full Names: | mesoderm development candidate 2 |
| NCBI Official Symbol: | MESDC2 |
| NCBI Official Synonym Symbols: | BOCA; MESD |
| NCBI Protein Information: | LDLR chaperone MESD |
| UniProt Protein Name: | LDLR chaperone MESD |
| UniProt Synonym Protein Names: | Mesoderm development candidate 2; Mesoderm development protein; Renal carcinoma antigen NY-REN-61 |
| Protein Family: | LDLR chaperone |
| UniProt Gene Name: | MESDC2 |
| UniProt Entry Name: | MESD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MESDC2 antibody (CAB13931) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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