ChIP Antibodies
Anti-MEPCE Antibody (CAB7121)
- SKU:
- CAB7121
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MEPCE Antibody |
| Antibody SKU: | CAB7121 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-689 of human MEPCE (NP_062552.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-689 of human MEPCE (NP_062552.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVGL DIDS RLIH SARQ NIRH YLSE ELRL PPQT LEGD PGAE GEEG TTTV RKRS CFPA SLTA SRGP IAAP QVPL DGAD TSVF PNNV VFVT GNYV LDRD DLVE AQTP EYDV VLCL SLTK WVHL NWGD EGLK RMFR RIYR HLRP GGIL VLEP QPWS SYGK RKTL TETI YKNY YRIQ LKPE QFSS YLTS PDVG FSSY ELVA TPHN TSKG FQRP VYLF HKAR SPSH |
| Gene ID: | 56257 |
| Uniprot: | Q7L2J0 |
| Cellular Location: | |
| Calculated MW: | 24kDa/74kDa |
| Observed MW: | Refer to figures |
| Synonyms: | MEPCE, BCDIN3 |
| Background: |
| UniProt Protein Function: | BCDIN3: a CDK9-associated enzyme that forms the distinctive gamma-methylphosphate cap structure of 7SK, a noncoding RNA that regulates CDK9 activity. An adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to its stabilization. Component of the 7SK snRNP complex that contains P-TEFb (composed of CDK9 and CCNT1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues. Contains a Bin3 domain found in a number of protein methyltransferases that modify RNA-binding proteins. |
| UniProt Protein Details: | Protein type:Transcription regulation; Methyltransferase; RNA processing; EC 2.1.1.; EC 2.1.1.- Chromosomal Location of Human Ortholog: 7q22.1 Molecular Function:RNA methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity Biological Process: RNA methylation; snRNA metabolic process; snRNA modification |
| UniProt Code: | Q7L2J0 |
| NCBI GenInfo Identifier: | 74758999 |
| NCBI Gene ID: | 56257 |
| NCBI Accession: | Q7L2J0.1 |
| UniProt Secondary Accession: | Q7L2J0,Q9NPD4, B3KP86, D6W5V7, |
| UniProt Related Accession: | Q7L2J0 |
| Molecular Weight: | 24,950 Da |
| NCBI Full Name: | 7SK snRNA methylphosphate capping enzyme |
| NCBI Synonym Full Names: | methylphosphate capping enzyme |
| NCBI Official Symbol: | MEPCE |
| NCBI Official Synonym Symbols: | BCDIN3 |
| NCBI Protein Information: | 7SK snRNA methylphosphate capping enzyme |
| UniProt Protein Name: | 7SK snRNA methylphosphate capping enzyme |
| UniProt Synonym Protein Names: | Bicoid-interacting protein 3 homolog; Bin3 homolog |
| Protein Family: | 7SK snRNA methylphosphate capping enzyme |
| UniProt Gene Name: | MEPCE |
| UniProt Entry Name: | MEPCE_HUMAN |
 | Immunofluorescence analysis of A549 cells using MEPCE antibody (CAB7121). |
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