Anti-MEKK2 Antibody (CAB19739)
- SKU:
- CAB19739
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MEKK2
- Synonyms:
- MEKK2B
- Research Area:
- Cell Biology
Description
| Product Name: | MEKK2 Rabbit mAb |
| Product Code: | CAB19739 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | MEKK2, MEKK2B |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human MEKK2 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, Jurkat, Mouse lung |
| Immunogen: | A synthesized peptide derived from human MEKK2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10746 |
| Uniprot: | Q9Y2U5 |
| Calculated MW: | 70kDa |
| Observed MW: | 78KDa |
| UniProt Protein Function: | MEKK2: a protein kinase of the STE11 family. Phosphorylates and activates MEK5. Involved in growth factor stimulated cell proliferation and differentiation. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, STE; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family Chromosomal Location of Human Ortholog: 2q14.3 Cellular Component: nucleoplasm; cytoplasm; cytosol Molecular Function:MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; metal ion binding; protein kinase binding; ATP binding; protein kinase activity Biological Process: activation of MAPKK activity; activation of MAPK activity; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; activation of JNK activity |
| NCBI Summary: | The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y2U5 |
| NCBI GenInfo Identifier: | 97536681 |
| NCBI Gene ID: | 10746 |
| NCBI Accession: | Q9Y2U5.2 |
| UniProt Related Accession: | Q9Y2U5 |
| Molecular Weight: | 70kDa |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 2 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 2 |
| NCBI Official Symbol: | MAP3K2 |
| NCBI Official Synonym Symbols: | MEKK2; MEKK2B |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 2 |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 2 |
| UniProt Synonym Protein Names: | MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2 |
| UniProt Gene Name: | MAP3K2 |
| UniProt Entry Name: | M3K2_HUMAN |
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