Anti-MED4 Antibody (CAB0623)
- SKU:
- CAB0623
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MED4
- Synonyms:
- ARC36
- Synonyms:
- DRIP36
- Synonyms:
- HSPC126
- Synonyms:
- TRAP36
- Synonyms:
- VDRIP
- Synonyms:
- mediator complex subunit 4
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | MED4 Rabbit mAb |
| Product Code: | CAB0623 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | MED4, ARC36, DRIP36, HSPC126, TRAP36, VDRIP, mediator complex subunit 4 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human MED4. |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | TE-1, Jurkat, U-87MG, Mouse lung, Rat liver |
| Immunogen: | A synthesized peptide derived from human MED4. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 29079 |
| Uniprot: | Q9NPJ6 |
| Cellular Location: | Nucleus |
| Calculated MW: | 35kDa |
| Observed MW: | 36KDa |
| UniProt Protein Function: | MED4: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 4 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 13q14.2 Cellular Component: nucleoplasm; membrane; Srb-mediator complex; nucleus Molecular Function:protein binding; ligand-dependent nuclear receptor transcription coactivator activity; vitamin D receptor binding; transcription cofactor activity; receptor activity; thyroid hormone receptor binding Biological Process: steroid hormone receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; gene expression |
| NCBI Summary: | This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q9NPJ6 |
| NCBI GenInfo Identifier: | 29840770 |
| NCBI Gene ID: | 29079 |
| NCBI Accession: | Q9NPJ6.1 |
| UniProt Secondary Accession: | Q9NPJ6,Q53GB4, Q53H68, Q5T912, Q6FHC4, Q6IA79, Q9BS95 Q9NYR5, B4DX67, |
| UniProt Related Accession: | Q9NPJ6 |
| Molecular Weight: | 24,947 Da |
| NCBI Full Name: | Mediator of RNA polymerase II transcription subunit 4 |
| NCBI Synonym Full Names: | mediator complex subunit 4 |
| NCBI Official Symbol: | MED4 |
| NCBI Official Synonym Symbols: | ARC36; VDRIP; DRIP36; TRAP36; HSPC126 |
| NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 4; TRAP/SMCC/PC2 subunit p36; mediator, 34-kD subunit, homolog; activator-recruited cofactor 36 kDa component; vitamin D receptor-interacting protein, 36-kD; vitamin D3 receptor-interacting protein complex 36 kDa component |
| UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 4 |
| UniProt Synonym Protein Names: | Activator-recruited cofactor 36 kDa component; ARC36; Mediator complex subunit 4; TRAP/SMCC/PC2 subunit p36 subunit; Vitamin D3 receptor-interacting protein complex 36 kDa component; DRIP36 |
| Protein Family: | Mediator of RNA polymerase II transcription |
| UniProt Gene Name: | MED4 |
| UniProt Entry Name: | MED4_HUMAN |
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