Cell Biology Antibodies 4

Anti-MECOM Antibody (CAB13669)

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SKU:
CAB13669
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MECOM Antibody
Antibody SKU:CAB13669
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human MECOM (NP_004982.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human MECOM (NP_004982.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MRSK GRAR KLAT NNEC VYGN YPEI PLEE MPDA DGVA STPS LNIQ EPCS PATS SEAF TPKE GSPY KAPI YIPD DIPI PAEF ELRE SNMP GAGL GIWT KRKI EVGE KFGP YVGE QRSN LKDP
Gene ID:2122
Uniprot:Q03112/Q13465
Cellular Location:Nucleus, Nucleus speckle
Calculated MW:18kDa/117kDa/118kDa/125kDa/139kDa
Observed MW:Refer to figures
Synonyms:MECOM, AML1-EVI-1, EVI1, KMT8E, MDS1, MDS1-EVI1, PRDM3, RUSAT2
Background:The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.
UniProt Protein Function:Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
NCBI Summary:The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
UniProt Code:Q03112
NCBI GenInfo Identifier:145559472
NCBI Gene ID:2122
NCBI Accession:Q03112.2
UniProt Secondary Accession:Q03112,Q16122, Q5HYI1, Q6MZS6, Q8NEI5, A1L4F3, A8KA00 B7Z8W7, B7ZLQ3, B7ZLQ4, C9JAK0, D3DNP7,
UniProt Related Accession:Q13465,Q03112
Molecular Weight:117,232 Da
NCBI Full Name:MDS1 and EVI1 complex locus protein EVI1
NCBI Synonym Full Names:MDS1 and EVI1 complex locus
NCBI Official Symbol:MECOM  
NCBI Official Synonym Symbols:EVI1; MDS1; PRDM3; RUSAT2; MDS1-EVI1; AML1-EVI-1  
NCBI Protein Information:MDS1 and EVI1 complex locus protein EVI1
UniProt Protein Name:MDS1 and EVI1 complex locus protein EVI1
UniProt Synonym Protein Names:Ecotropic virus integration site 1 protein homolog; EVI-1
Protein Family:MDS1 and EVI1 complex locus protein
UniProt Gene Name:MECOM  
UniProt Entry Name:EVI1_HUMAN
Anti-MECOM Antibody (CAB13669)Immunofluorescence analysis of HeLa cells using MECOM antibody (CAB13669). Blue: DAPI for nuclear staining.
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