Anti-MDH1 Antibody (CAB9673)
- SKU:
- CAB9673
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HEL-S-32
- Synonyms:
- MDH-s
- Synonyms:
- MDHA
- Synonyms:
- MGC:1375
- Synonyms:
- MOR2
- Research Area:
- Metabolism
Description
| Product Name: | MDH1 Rabbit mAb |
| Product Code: | CAB9673 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | HEL-S-32, MDH-s, MDHA, MGC:1375, MOR2 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human MDH1 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat, U-251MG, Mouse liver, Mouse brain, Rat kidney, Rat heart |
| Immunogen: | A synthesized peptide derived from human MDH1 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4190 |
| Uniprot: | P40925 |
| Calculated MW: | 36kDa |
| Observed MW: | 36kDa |
| UniProt Protein Function: | MDH1: Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Nov 2010] |
| UniProt Protein Details: | Protein type:EC 1.1.1.96; Carbohydrate Metabolism - pyruvate; Oxidoreductase; Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.37; Carbohydrate Metabolism - glyoxylate and dicarboxylate Chromosomal Location of Human Ortholog: 2p13.3 Cellular Component: centrosome; extracellular space; mitochondrion; cytoplasm; cytosol Molecular Function:malic enzyme activity; L-malate dehydrogenase activity; diiodophenylpyruvate reductase activity; NAD binding Biological Process: malate metabolic process; oxaloacetate metabolic process; NADH metabolic process; tricarboxylic acid cycle; carbohydrate metabolic process; glucose metabolic process; cellular carbohydrate metabolic process; pathogenesis; gluconeogenesis |
| NCBI Summary: | This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Feb 2016] |
| UniProt Code: | P40925 |
| NCBI GenInfo Identifier: | 1708967 |
| NCBI Gene ID: | 4190 |
| NCBI Accession: | P40925.4 |
| UniProt Related Accession: | P40925 |
| Molecular Weight: | ~ 36kDa |
| NCBI Full Name: | Malate dehydrogenase, cytoplasmic |
| NCBI Synonym Full Names: | malate dehydrogenase 1 |
| NCBI Official Symbol: | MDH1 |
| NCBI Official Synonym Symbols: | MDHA; MOR2; MDH-s; HEL-S-32; MGC:1375 |
| NCBI Protein Information: | malate dehydrogenase, cytoplasmic; malate dehydrogenase, peroxisomal |
| UniProt Protein Name: | Malate dehydrogenase, cytoplasmic |
| UniProt Synonym Protein Names: | Cytosolic malate dehydrogenase; Diiodophenylpyruvate reductase (EC:1.1.1.96) |
| Protein Family: | Malate dehydrogenase |
| UniProt Gene Name: | MDH1 |
| UniProt Entry Name: | MDHC_HUMAN |
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